Nanotechnology for topical drug delivery to the anterior segment of the eye

A Vaneev, V Tikhomirova, N Chesnokova… - International journal of …, 2021 - mdpi.com
Topical drug delivery is one of the most challenging aspects of eye therapy. Eye drops are
the most prevalent drug form, especially for widely distributed anterior segment eye …

Contact lenses as ophthalmic drug delivery systems: A review

P Franco, I De Marco - Polymers, 2021 - mdpi.com
Ophthalmic drugs used for the treatment of various ocular diseases are commonly
administered by eye drops. However, due to anatomical and physiological factors, there is a …

A review on albumin as a biomaterial for ocular drug delivery

R Tiwari, NK Sethiya, AS Gulbake, NK Mehra… - International Journal of …, 2021 - Elsevier
Abstract Development of ocular drug delivery system is one of the most technically
challenging tasks, when compared with other routes of drug delivery. Eye (an intricate …

A grafted copolymer-based nanomicelles for topical ocular delivery of everolimus: Formulation, characterization, ex-vivo permeation, in-vitro ocular toxicity, and …

N Mehra, M Aqil, Y Sultana - European Journal of Pharmaceutical Sciences, 2021 - Elsevier
Abstract Treatment of posterior uveitis via topical route is desirable but cannot be achieved
by conventional drug delivery strategies. Therefore, the aim of this study is to develop a …

Prodrugs and nanomicelles to overcome ocular barriers for drug penetration

V Gote, M Ansong, D Pal - Expert Opinion on Drug Metabolism & …, 2020 - Taylor & Francis
Introduction Ocular barriers hinder drug delivery and reduce drug bioavailability. This article
focuses on enhancing drug absorption across the corneal and conjunctival epithelium. Both …

Nanoparticles in ocular applications and their potential toxicity

C Yang, J Yang, A Lu, J Gong, Y Yang, X Lin… - Frontiers in molecular …, 2022 - frontiersin.org
Nanotechnology has been developed rapidly in recent decades and widely applied in
ocular disease therapy. Nano-drug delivery systems overcome the bottlenecks of current …

Phosphorylcholine-Based Contact Lenses for Sustained Release of Resveratrol: Design, Antioxidant and Antimicrobial Performances, and In Vivo Behavior

M Vivero-Lopez, AF Pereira-da-Mota… - … Applied Materials & …, 2022 - ACS Publications
Design of advanced contact lenses (CLs) demands materials that are safe and comfortable
for the wearers and that preserve the normal eye microbiota, avoiding chronic inflammation …

[HTML][HTML] PluronicŪ/casein micelles for ophthalmic delivery of resveratrol: In vitro, ex vivo, and in vivo tests

M Vivero-Lopez, C Sparacino… - International Journal of …, 2022 - Elsevier
Ocular health may strongly benefit from the supply of antioxidant agents that counteract free
radicals and reactive oxygen species responsible for long-term eye diseases. Additionally …

Role of polymeric micelles in Ocular Drug Delivery: an overview of decades of Research

Z Binkhathlan, R Ali, AH Alomrani… - Molecular …, 2023 - ACS Publications
Local drug delivery to the eye through conventional means has faced many challenges due
to three essential barriers:(a) the complex structure of the cornea limiting drug absorption,(b) …

Advances in biomaterials for the treatment of retinoblastoma

W Farhat, V Yeung, A Ross, F Kahale, N Boychev… - Biomaterials …, 2022 - pubs.rsc.org
Retinoblastoma is the most common primary intraocular malignancy in children. Although
traditional chemotherapy has shown some success in retinoblastoma management, there …