Production of recombinant proteins by filamentous fungi

OP Ward - Biotechnology advances, 2012 - Elsevier
The initial focus of recombinant protein production by filamentous fungi related to exploiting
the extraordinary extracellular enzyme synthesis and secretion machinery of industrial …

Approaches to functional genomics in filamentous fungi

RJ Weld, KM Plummer, MA Carpenter, HJ Ridgway - Cell research, 2006 - nature.com
The study of gene function in filamentous fungi is a field of research that has made great
advances in very recent years. A number of transformation and gene manipulation strategies …

Fusion PCR and gene targeting in Aspergillus nidulans

E Szewczyk, T Nayak, CE Oakley, H Edgerton… - Nature protocols, 2006 - nature.com
We describe a rapid method for the production of fusion PCR products that can be used,
generally without band purification, to transform Aspergillus nidulans. This technique can be …

Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway

YM Chiang, E Szewczyk, T Nayak, AD Davidson… - Chemistry & biology, 2008 - cell.com
The recently sequenced genomes of several Aspergillus species have revealed that these
organisms have the potential to produce a surprisingly large range of natural products, many …

The Fumitremorgin Gene Cluster of Aspergillus fumigatus: Identification of a Gene Encoding Brevianamide F Synthetase

S Maiya, A Grundmann, SM Li, G Turner - ChemBioChem, 2006 - Wiley Online Library
A gene encoding a putative dimodular nonribosomal peptide synthetase (NRPS) was
identified within a gene cluster of Aspergillus fumigatus, a species reported to produce …

In the fungus where it happens: history and future propelling Aspergillus nidulans as the archetype of natural products research

LK Caesar, NL Kelleher, NP Keller - Fungal Genetics and Biology, 2020 - Elsevier
In 1990 the first fungal secondary metabolite biosynthetic gene was cloned in Aspergillus
nidulans. Thirty years later,> 30 biosynthetic gene clusters (BGCs) have been linked to …

Physiology and biotechnology of Aspergillus

OP Ward, WM Qin, J Dhanjoon, J Ye, A Singh - Advances in applied …, 2005 - Elsevier
Publisher Summary This chapter discusses the physiology and biotechnology of Aspergillus
species. The genus Aspergillus is found worldwide and consists of more than 180 officially …

Efficient PCR-based gene targeting with a recyclable marker for Aspergillus nidulans

ML Nielsen, L Albertsen, G Lettier, JB Nielsen… - Fungal Genetics and …, 2006 - Elsevier
The rapid accumulation of genomic sequences from a large number of eukaryotes, including
numerous filamentous fungi, has created a tremendous scientific potential, which can only …

Cell polarity in filamentous fungi: shaping the mold

SD Harris - International review of cytology, 2006 - Elsevier
The formation of highly polarized hyphae that grow by apical extension is a defining feature
of the filamentous fungi. High‐resolution microscopy and mathematical modeling have …

Deletion of the putative stretch-activated ion channel Mid1 is hypervirulent in Aspergillus fumigatus

H Jiang, Y Shen, W Liu, L Lu - Fungal Genetics and Biology, 2014 - Elsevier
Calcium ion is a universal and physiologically important molecule affecting almost every
cellular function, while Mid1 (mating induced death) is a stretch-activated ion channel …