Breast cancer is a very heterogeneous disease, both at a molecular and a histological level.
Five intrinsic subtypes were initially identified—Luminal-A, Luminal-B, HER2+, Triple …

Most recent investigations into cancer etiology have identified a key role played by
epigenetics. Specifically, aberrant DNA and histone modifications which silence tumor …

Background Breast cancer formation is associated with frequent changes in DNA
methylation but the extent of very early alterations in DNA methylation and the biological …

Background We examined whether differences in tumor DNA methylation were associated
with more aggressive hormone receptor-negative breast cancer in an ethnically diverse …

Gene-specific methylation alterations in breast cancer have been suggested to occur early
in tumorigenesis and have the potential to be used for early detection and prevention. The …

Whole-blood DNA methylation markers have been suggested as potential biomarkers for
early detection of breast cancer. We conducted a systematic review of the literature on whole …

Aberrant DNA methylation is considered to be one of the most common hallmarks of cancer.
Several recent advances in assessing the DNA methylome provide great promise for …

Abstract Background: African American (AA) women are diagnosed with more advanced
breast cancers and have worse survival than white women, but a comprehensive …

Breast malignancies are the leading type of cancer among women. Its prevention and early
detection, particularly in young women, remains challenging. To this end, cell-free DNA …

Background: Although obesity is associated with breast cancer incidence and prognosis, the
underlying mechanisms are poorly understood. Identification of obesity-associated …