Bacterial infections are increasingly resistant to antimicrobial therapy. Intense research
focus has thus been placed on identifying the mechanisms that bacteria use to resist killing …

Mycobacterial species, including Mycobacterium tuberculosis, rely on lipids to survive and
chronically persist within their hosts. Upon infection, opportunistic and strict pathogenic …

Branched-chain amino acids (primarily isoleucine) are important regulators of virulence and
are converted to precursor molecules used to initiate fatty acid synthesis in Staphylococcus …

All free-living microorganisms homeostatically maintain the fluidity of their membranes by
adapting lipid composition to environmental temperatures. Here, we quantify enzymes and …

Growth and division are central to cell size. Bacteria achieve size homeostasis by dividing
when growth has added a constant size since birth, termed the adder principle, by unknown …

Bacterial fatty acid synthesis in Escherichia coli is initiated by the condensation of an acetyl-
CoA with a malonyl-acyl carrier protein (ACP) by the β-ketoacyl-ACP synthase III enzyme …

Formed by aberrant cell division, minicells possess functional metabolism despite their
inability to grow and divide. Minicells exhibit not only superior stability when compared with …

Understanding metabolic heterogeneity is critical for optimizing microbial production of
valuable chemicals, but requires tools that can quantify metabolites at the single‐cell level …

The molecule guanosine tetraphophosphate (ppGpp) is most commonly considered an
alarmone produced during acute stress. However, ppGpp is also present at low …

Bacteria surround themselves with complex cell envelopes to maintain their integrity and
protect against external insults. The envelope of Gram-negative organisms is multilayered …