Cancer is the second leading cause of death worldwide and disease burden is expected to
increase globally throughout the next several decades, with the majority of cancer-related …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

Background Drugs targeting the spindle assembly checkpoint (SAC), such as inhibitors of
Aurora kinase B (AURKB) and dual specific protein kinase TTK, are in different stages of …

With the high morbidity and mortality, hepatocellular carcinoma (HCC) represents a major
yet growing burden for our global community. The relapse-prone nature and drug resistance …

Breast cancer (BC) is the malignancy with the highest mortality rate among women,
identification of immune-related biomarkers facilitates precise diagnosis and improvement of …

Monopolar spindle kinase 1 (MPS1) plays a pivotal role as a dual-specificity kinase
governing spindle assembly checkpoint activation and sister chromatid separation in …

One of the leading causes of death (20.1 per 100,000 women per year), breast cancer is the
most prevalent cancer in females. Statistically, 95% of breast cancer are categorized as …

Abstract Annexin A2 (ANXA2) is a widely reported oncogene. However, the mechanism of
ANXA2 in esophageal cancer is not fully understood. In this study, we provided evidence …

Head and neck cancer (HNC), the sixth most common cancer worldwide, is increasing in
incidence, with oral squamous cell carcinoma (OSCC) as the predominant subtype. OSCC …

Viral mimicry driven by endogenous double-stranded RNA (dsRNA) stimulates innate and
adaptive immune responses. However, the mechanisms that regulate dsRNA-forming …