Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with
lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial …

Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …

Immune cell development and activation demand the precise and coordinated control of
transcriptional programmes. Three-dimensional (3D) organization of the genome has …

Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant
cancers, and patients with HNSCC possess early metastases and poor prognosis …

Parasites impose fitness costs on their hosts. Biologists often assume that natural selection
favors infection-resistant hosts. Yet, when the immune response itself is costly, theory …

Neutrophils are key cells of the innate immune system. It is now understood that this
leukocyte population is diverse in both the basal composition and functional plasticity …

Here we present a comprehensive HiChIP dataset on naïve CD4 T cells (nCD4) from 30
donors and identify QTLs that associate with genotype-dependent and/or allele-specific …

Transcriptional enhancers play a key role in the initiation and maintenance of gene
expression programmes, particularly in metazoa. How these elements control their target …

Driven by co‐evolution with pathogens, host immunity continuously adapts to optimize
defence against pathogens within a given environment. Recent advances in genetics …

The resolution of causal genetic variants informs understanding of disease biology. We used
regulatory quantitative trait loci (QTLs) from the BLUEPRINT, GTEx and eQTLGen projects to …