Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …

Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver
disease worldwide (about 25% of the general population) and 3–5% of patients develop non …

Endocannabinoids acting via CB 1 receptors (CB 1 R) play a critical role in regulating
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …

Hepatic fibrosis (HF) is a prevalent and irreversible liver disease caused by unhealthy
lifestyles. However, no specific diagnosis tools, except for liver biopsy, are available for HF …

Damage-associated molecular patterns are signalling molecules involved in inflammatory
responses and restoration of homeostasis. Chronic release of these molecules can also …

Fibrosis is defined as the pathological progress of excessive extracellular matrix (ECM),
such as collagen, fibronectin, and elastin deposition, as the regenerative capacity of cells …

Background & Aims Development of nonalcoholic steatohepatitis (NASH) is associated with
reductions in hepatic microRNA122 (MIR122); the RAR related orphan receptor A (RORA) …

AP-1, activator protein-1; BH4, tetrahydrobiopterin; cGMP, cyclic guanosine
monophosphate; ECMs, extracellular matrix proteins; eNOS, endothelial nitric oxide …

Chronic liver injury can lead to hepatic failure and the only available method of treatment
would be liver transplantation. The link between inflammation (TNF-α), nuclear factor-kappa …

Hepatic injury is a major side effect associated with methotrexate (MTX) therapy resulting
from inflammatory reactions and oxidative stress induction. Therefore, liver fibrosis incidence …