While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-
dependent deacylases with remarkable abilities to prevent diseases and even reverse …

The mammalian sirtuins (SIRT1–7) are NAD+-dependent lysine deacylases that play central
roles in cell survival, inflammation, energy metabolism, and aging. Members of this family of …

Aims/hypothesis Homo sapiens evolved under conditions of intermittent food availability and
prolonged fasting between meals. Periods of fasting are important for recovery from meal …

Age is the most important risk factor for diseases affecting the Western world, and slowing
age‐related degeneration would greatly improve the quality of human life. In rodents, caloric …

Myricetin is a naturally occurring flavonol found in many plant based food sources. It
increases the lifespan of Caenorhabditis elegans, but the molecular mechanisms are not yet …

The sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD+)-
dependent histone deacetylases that helps regulate the lifespan of diverse organisms. The …

Aging constitutes progressive physiological changes in an organism. These changes alter
the normal biological functions, such as the ability to manage metabolic stress, and …

Reactive oxygen species (ROS) are potentially toxic, but they are also signaling molecules
that modulate aging. Recent observations that ROS can promote longevity have to be …

Significance: Calorie restriction (CR) is a known intervention that delays most aging
processes. Most of the beneficial effects of CR are mediated by improved maintenance of …