Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to
regimens that are both expensive and associated with toxic effects. A curative intervention …

The development of drugs for HIV infection began soon after the virus was discovered 25
years ago. Since then, progress has been substantial, but numerous uncertainties persist …

Background Used in combination with antiretroviral therapy, subcutaneous recombinant
interleukin-2 raises CD4+ cell counts more than does antiretroviral therapy alone. The …

Combination antiretroviral therapy (ART) has altered the outcomes of HIV infection in treated
populations by greatly reducing the incidence of opportunistic infections, cancer, and HIV …

Cytokines that signal through receptor complexes containing the common γ (γC) chain
receptor subunit are central regulators of lymphocyte homeostasis. In this review, we discuss …

The immune system consists of a diverse array of immunocompetent cells and inflammatory
mediators that exist in complex networks. These components interact through cascades and …

While highly active antiretroviral therapy (HAART) regimens have proven to be effective in
controlling active HIV replication, complete recovery of CD4+ T cells does not always occur …

The common gamma chain (γc)-sharing cytokines (IL's-2, 4, 7, 9, 15, and 21) play a vital role
in the survival, proliferation, differentiation and function of T lymphocytes. As such, disruption …

CD4+ T cell depletion is a fundamental component of HIV infection and AIDS pathogenesis
and is not always reversed following antiretroviral therapy (ART). In this study, the SIV …

Control of viral replication to below the level of quantification using combination antiretroviral
therapy (ART)[cART] has led to a dramatic fall in mortality and morbidity from AIDS …