Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

Neutrophils play a key role in defence against infection and in the activation and regulation
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …

The role and importance of neutrophils in cancer has become increasingly apparent over
the past decade. Neutrophils accumulate in the peripheral blood of patients with cancer …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a
non-uniform phenotype and diverse functional activities. Both tumor-associated …

Neutrophils, which are the most abundant circulating leukocytes in humans, are the first line
of defense against bacterial and fungal infections. Recent studies have reported the role and …

Nearly two-thirds of cancer patients are treated with radiation therapy (RT), often with the
intent to achieve complete and permanent tumor regression (local control). RT is the primary …

Methods We performed a narrative review of the literature in the PubMed database. The
research string comprised various combinations of “radiotherapy”,“programmed death …

Bone metastasis is associated with significant morbidity for cancer patients and results in a
reduced quality of life. The bone marrow is a fertile soil containing a complex composition of …

Metastasis, a primary cause of death in patients with malignancies, is promoted by intrinsic
changes in both tumor and non-malignant cells in the tumor microenvironment (TME). As …