Branched-chain amino acid biosynthesis in fungi

JT Steyer, RB Todd - Essays in Biochemistry, 2023 - portlandpress.com
Branched-chain amino acids (BCAAs)—isoleucine, leucine, and valine—are synthesized by
fungi. These amino acids are important components of proteins and secondary metabolites …

Nitrogen, Iron, and Zinc Acquisition: Key Nutrients to Aspergillus fumigatus Virulence

U Perez-Cuesta, X Guruceaga, S Cendon-Sanchez… - Journal of Fungi, 2021 - mdpi.com
Aspergillus fumigatus is a ubiquitous soil decomposer and an opportunistic pathogen that is
characterized by its large metabolic machinery for acquiring nutrients from media. Lately, an …

Prevalence of transcription factors in ascomycete and basidiomycete fungi

RB Todd, M Zhou, RA Ohm, HACF Leeggangers… - BMC genomics, 2014 - Springer
Background Gene regulation underlies fungal physiology and therefore is a major factor in
fungal biodiversity. Analysis of genome sequences has revealed a large number of putative …

Global gene expression during nitrogen starvation in the rice blast fungus, Magnaporthe grisea

NM Donofrio, Y Oh, R Lundy, H Pan, DE Brown… - Fungal Genetics and …, 2006 - Elsevier
Efficient regulation of nitrogen metabolism likely plays a role in the ability of fungi to exploit
ecological niches. To learn about regulation of nitrogen metabolism in the rice blast …

Characterization of the Aspergillus niger prtT, a unique regulator of extracellular protease encoding genes

PJ Punt, FHJ Schuren, J Lehmbeck… - Fungal Genetics and …, 2008 - Elsevier
Expression of several Aspergillus niger genes encoding major secreted, but not vacuolar,
protease genes including the major acid protease gene pepA, was shown to be affected in …

The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus

N Long, T Orasch, S Zhang, L Gao, X Xu… - PLoS …, 2018 - journals.plos.org
Both branched-chain amino acids (BCAA) and iron are essential nutrients for eukaryotic
cells. Previously, the Zn2Cys6-type transcription factor Leu3/LeuB was shown to play a …

H2O2 induces major phosphorylation changes in critical regulators of signal transduction, gene expression, metabolism and developmental networks in Aspergillus …

U Carrasco-Navarro, J Aguirre - Journal of Fungi, 2021 - mdpi.com
Reactive oxygen species (ROS) regulate several aspects of cell physiology in filamentous
fungi including the antioxidant response and development. However, little is known about …

Role of the nitrogen metabolism regulator TAM1 in regulation of cellulase gene expression in Trichoderma reesei

R Yang, Z Wang, Y Xia, F Zheng, F Kang… - Applied and …, 2023 - Am Soc Microbiol
The filamentous fungus Trichoderma reesei is one of the most prolific cellulase producers
and has been established as a model microorganism for investigating mechanisms …

Duplication and functional divergence of branched-chain amino acid biosynthesis genes in Aspergillus nidulans

JT Steyer, DJ Downes, CC Hunter, PA Migeon… - Mbio, 2021 - Am Soc Microbiol
Fungi, bacteria, and plants, but not animals, synthesize the branched-chain amino acids:
leucine, isoleucine, and valine. While branched-chain amino acid (BCAA) biosynthesis has …

The regulatory mechanism of water activities on aflatoxins biosynthesis and conidia development, and transcription factor AtfB is involved in this regulation

L Ma, X Li, X Ma, Q Yu, X Yu, Y Liu, C Nie, Y Zhang… - Toxins, 2021 - mdpi.com
Peanuts are frequently infected by Aspergillus strains and then contaminated by aflatoxins
(AF), which brings out economic losses and health risks. AF production is affected by diverse …