Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
RJ Weaver, EA Blomme, AE Chadwick… - Nature Reviews Drug …, 2020 - nature.com
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …
pathophysiological process that cannot yet be recapitulated in a single in vitro model …
Genetic, epigenetic, and environmental contributions to neural tube closure
JJ Wilde, JR Petersen, L Niswander - Annual review of genetics, 2014 - annualreviews.org
The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …
Structure of the human SAGA coactivator complex
The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification,
DNA damage repair and signaling. While structures of yeast SAGA (ySAGA) have been …
DNA damage repair and signaling. While structures of yeast SAGA (ySAGA) have been …
Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives
Cellular stress induced by the accumulation of misfolded proteins at the endoplasmic
reticulum (ER) is a central feature of secretory cells and is observed in many tissues in …
reticulum (ER) is a central feature of secretory cells and is observed in many tissues in …
Histone modifiers in cancer: friends or foes?
Covalent modifications of histones can regulate all DNA-dependent processes. In the last
few years, it has become more and more evident that histone modifications are key players …
few years, it has become more and more evident that histone modifications are key players …
ATAC-king the complexity of SAGA during evolution
G Spedale, HTM Timmers… - Genes & …, 2012 - genesdev.cshlp.org
The yeast SAGA (Spt–Ada–Gcn5–acetyltransferase) coactivator complex exerts functions in
gene expression, including activator interaction, histone acetylation, histone …
gene expression, including activator interaction, histone acetylation, histone …
The human TREX-2 complex is stably associated with the nuclear pore basket
D Umlauf, J Bonnet, F Waharte… - Journal of cell …, 2013 - journals.biologists.com
In eukaryotes, mRNA export involves many evolutionarily conserved factors that carry the
nascent transcript to the nuclear pore complex (NPC). The THO/TREX complex couples …
nascent transcript to the nuclear pore complex (NPC). The THO/TREX complex couples …
Dynamic modules of the coactivator SAGA in eukaryotic transcription
Abstract SAGA (Spt-Ada-Gcn5 acetyltransferase) is a highly conserved transcriptional
coactivator that consists of four functionally independent modules. Its two distinct enzymatic …
coactivator that consists of four functionally independent modules. Its two distinct enzymatic …
Insights into SAGA function during gene expression
S Rodríguez‐Navarro - EMBO reports, 2009 - embopress.org
Histone modifications are a crucial source of epigenetic control. SAGA (Spt–Ada–Gcn5
acetyltransferase) is a chromatin‐modifying complex that contains two distinct enzymatic …
acetyltransferase) is a chromatin‐modifying complex that contains two distinct enzymatic …
[HTML][HTML] Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons
Abstract Background Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants
originating from petrogenic and pyrogenic sources. PAH compounds can cross the placenta …
originating from petrogenic and pyrogenic sources. PAH compounds can cross the placenta …