Dendritic cells (DCs) represent a small and heterogeneous fraction of the hematopoietic
system, specialized in antigen capture, processing, and presentation. The different DC …

During homeostasis, interactions between tolerogenic dendritic cells (DCs), self-reactive T
cells, and T regulatory cells (Tregs) contribute to maintaining mammalian immune tolerance …

Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high
amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic …

CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-
mediated tumor rejection, but the underlying mechanisms are incompletely understood …

Inhibition of glycolysis in immune cells and cancer cells diminishes their activity, and thus
combining immunotherapies with glycolytic inhibitors is challenging. Herein, a strategy is …

The effects of acute exposure to low-and high-dose radiation on the quantitative and
functional parameters of the immune system were analyzed. C57BL/6 mice were irradiated …

Dendritic cells (DCs) are antigen-presenting cells (APCs) that are essential for the activation
of immune responses. In various malignancies, these immunostimulatory properties are …

Background Therapeutic vaccination against disseminated prostate cancer (PCa) is partially
effective in some PCa patients. We hypothesized that the efficacy of treatment will be …

Dendritic cells are the most potent antigen-presenting cells known; owing to their ability to
stimulate antigen-specific cytolytic and memory T-cell responses, their use as cancer …

Abstract Liver Kinase B1 (LKB1) plays a key role in cellular metabolism by controlling AMPK
activation. However, its function in dendritic cell (DC) biology has not been addressed. Here …