Calcium dynamics as a machine for decoding signals
Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …
Calcium signaling and cell cycle: Progression or death
J Humeau, JM Bravo-San Pedro, I Vitale, L Nunez… - Cell calcium, 2018 - Elsevier
Cytosolic Ca 2+ concentration levels fluctuate in an ordered manner along the cell cycle, in
line with the fact that Ca 2+ is involved in the regulation of cell proliferation. Cell proliferation …
line with the fact that Ca 2+ is involved in the regulation of cell proliferation. Cell proliferation …
Store-operated Ca2+ entry controls clonal expansion of T cells through metabolic reprogramming
Summary Store-operated Ca 2+ entry (SOCE) is the main Ca 2+ influx pathway in
lymphocytes and is essential for T cell function and adaptive immunity. SOCE is mediated by …
lymphocytes and is essential for T cell function and adaptive immunity. SOCE is mediated by …
Mitochondrial Ca2+ Signaling in Health, Disease and Therapy
The divalent cation calcium (Ca2+) is considered one of the main second messengers
inside cells and acts as the most prominent signal in a plethora of biological processes. Its …
inside cells and acts as the most prominent signal in a plethora of biological processes. Its …
Store-operated Ca2+ entry controls induction of lipolysis and the transcriptional reprogramming to lipid metabolism
Ca 2+ signals were reported to control lipid homeostasis, but the Ca 2+ channels and
pathways involved are largely unknown. Store-operated Ca 2+ entry (SOCE) is a ubiquitous …
pathways involved are largely unknown. Store-operated Ca 2+ entry (SOCE) is a ubiquitous …
GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells
Endoplasmic reticulum (ER) membrane contact sites (MCSs) are crucial regulatory hubs in
cells, playing roles in signaling, organelle dynamics, and ion and lipid homeostasis …
cells, playing roles in signaling, organelle dynamics, and ion and lipid homeostasis …
Baicalein as promising anticancer agent: A comprehensive analysis on molecular mechanisms and therapeutic perspectives
AKMH Morshed, S Paul, A Hossain, T Basak… - Cancers, 2023 - mdpi.com
Simple Summary Cancer is a multifactorial disease characterized by excessive cell
proliferation in a specific organ. The most common treatments include chemotherapy …
proliferation in a specific organ. The most common treatments include chemotherapy …
The Interplay between Ca2+ Signaling Pathways and Neurodegeneration
RP Ureshino, AG Erustes, TB Bassani… - International journal of …, 2019 - mdpi.com
Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in
many physiological processes. For example, the spatial and temporal organization of Ca2+ …
many physiological processes. For example, the spatial and temporal organization of Ca2+ …
Ion channels in the regulation of autophagy
A Kondratskyi, K Kondratska, R Skryma, DJ Klionsky… - Autophagy, 2018 - Taylor & Francis
Autophagy is a cellular process in which the cell degrades and recycles its own constituents.
Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is …
Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is …
Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation
The role of the mitochondrial Ca2+ uniporter (MCU) in physiologic cell proliferation remains
to be defined. Here, we demonstrated that the MCU was required to match mitochondrial …
to be defined. Here, we demonstrated that the MCU was required to match mitochondrial …