Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen
outcome. Hypertension is prevalent in the stroke population and the most important …

Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …

Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a
healthy cardiovascular system. The importance of eNOS can be emphasized from the …

Blood–brain barrier (BBB) leakage plays a key role in cerebral ischemia–reperfusion injury.
It is quite necessary to further explore the characteristic and mechanism of BBB leakage …

Essential hypertension has devastating effects on the brain, being the major cause of stroke
and a leading cause of dementia. Hypertension alters the structure of cerebral blood vessels …

BACKGROUND AND PURPOSE: The regional leptomeningeal score is a strong and
reliable imaging predictor of good clinical outcomes in acute anterior circulation ischemic …

Angiotensin II receptor blockers (ARBs, collectively called sartans) are widely used
compounds therapeutically effective in cardiovascular disorders, renal disease, the …

Context There is a paucity of effective, well-tolerated drugs available for migraine
prophylaxis. Objective To determine whether treatment with the angiotensin II receptor …

The effects of brain AngII (angiotensin II) depend on AT1 receptor (AngII type 1 receptor)
stimulation and include regulation of cerebrovascular flow, autonomic and hormonal …

Poor adaptation to stress, alterations in cerebrovascular function and excessive brain
inflammation play critical roles in the pathophysiology of many psychiatric and neurological …