The Cannabis plant has been used for many of years as a medicinal agent in the relief of
pain and seizures. It contains approximately 540 natural compounds including more than …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …

Pain results from the complex processing of neural signals at different levels of the central
nervous system, with each signal potentially offering multiple opportunities for …

Abstract The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the
large TRP family of ion channels, and functions as a Ca 2+ permeable non-selective cation …

The thermo‐transient receptor potentials (TRPs), a recently discovered family of ion
channels activated by temperature, are expressed in primary sensory nerve terminals where …

Tooth infections or injuries involving dental pulp are treated routinely by root canal therapy.
Endodontically treated teeth are devitalized, susceptible to re-infections, fractures, and …

Background: Safe and effective treatment for chronic inflammatory and neuropathic pain
remains a key unmet medical need for many patients. The recent discovery and description …

Mechanical hyperalgesia is a clinically-relevant form of pain sensitization that develops
through largely unknown mechanisms. TRPA1, a Transient Receptor Potential ion channel …

The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …