Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors

L Miao, CM Lin, L Huang - Journal of Controlled Release, 2015 - Elsevier
Nanoparticle based delivery formulations have become a leading delivery strategy for
cancer imaging and therapy. The success of nanoparticle-based therapy relies heavily on …

Nanoformulations for combination or cascade anticancer therapy

L Miao, S Guo, CM Lin, Q Liu, L Huang - Advanced drug delivery reviews, 2017 - Elsevier
Nanoparticle drug formulations have been extensively investigated, developed, and in some
cases, approved by the Food and Drug Administration (FDA). Synergistic combinations of …

Targeting renin–angiotensin system against Alzheimer's disease

AK Gebre, BM Altaye, TM Atey, KB Tuem… - Frontiers in …, 2018 - frontiersin.org
Renin Angiotensin System (RAS) is a hormonal system that regulates blood pressure and
fluid balance through a coordinated action of renal, cardiovascular, and central nervous …

Renin-angiotensin system: The underlying mechanisms and promising therapeutical target for depression and anxiety

S Gong, F Deng - Frontiers in Immunology, 2023 - frontiersin.org
Emotional disorders, including depression and anxiety, contribute considerably to morbidity
across the world. Depression is a serious condition and is projected to be the top contributor …

Oxidative stress implications in the affective disorders: main biomarkers, animal models relevance, genetic perspectives, and antioxidant approaches

IM Balmus, A Ciobica, I Antioch… - … medicine and cellular …, 2016 - Wiley Online Library
The correlation between the affective disorders and the almost ubiquitous pathological
oxidative stress can be described in a multifactorial way, as an important mechanism of …

Aβ-accelerated neurodegeneration caused by Alzheimer's-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice

LK Cuddy, D Prokopenko, EP Cunningham… - Science translational …, 2020 - science.org
Recent genome-wide association studies identified the angiotensin-converting enzyme
gene (ACE) as an Alzheimer's disease (AD) risk locus. However, the pathogenic mechanism …

New and old roles of the peripheral and brain renin–angiotensin–aldosterone system (RAAS): focus on cardiovascular and neurological diseases

A Mascolo, M Sessa, C Scavone, A De Angelis… - International Journal of …, 2017 - Elsevier
It is commonly accepted that the renin–angiotensin–aldosterone system (RAAS) is a
cardiovascular circulating hormonal system that plays also an important role in the …

Impact of the renin-angiotensin system on the pathogeny and pharmacotherapeutics of neurodegenerative diseases

W Bild, A Vasincu, RN Rusu, DC Ababei, AB Stana… - Biomolecules, 2022 - mdpi.com
Brain neurodegenerative diseases (BND) are debilitating conditions that are especially
characteristic of a certain period of life and considered major threats to human health …

The involvement of renin-angiotensin system in lipopolysaccharide-induced behavioral changes, neuroinflammation, and disturbed insulin signaling

X Gong, H Hu, YI Qiao, P Xu, M Yang… - Frontiers in …, 2019 - frontiersin.org
Brain insulin signaling is accounted for the development of a variety of neuropsychiatric
disorders, such as anxiety and depression, whereas both inflammation and the activated …

Angiotensin II and its receptor in activated microglia enhanced neuronal loss and cognitive impairment following pilocarpine-induced status epilepticus

H Sun, HQ Wu, X Yu, GL Zhang, R Zhang… - Molecular and Cellular …, 2015 - Elsevier
Neuroinflammation plays a role in the pathology of epilepsy and in cognitive impairment.
Angiotensin II (AII) and the angiotensin receptor type 1 (AT1) have been shown to regulate …