The 2016 revised fourth edition of the World Health Organization (WHO) classification of
central nervous system (CNS) tumors incorporated molecular features with histologic …

Importance Previous histologic classifications of brain tumors have been limited by
discrepancies in diagnoses reported by neuropathologists and variability in outcomes and …

Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant
primary brain tumors diagnosed in patients younger than 50, constituting an important cause …

Correcting the drug development paradigm for glioblastoma requires serial tissue sampling |
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Glioblastomas (GBMs) are aggressive primary brain tumors with fatal outcome. Traditional
chemo-radiotherapy has poor therapeutic effect and significant side effects, due to the drug …

PURPOSE To provide updated evidence-and consensus-based guideline
recommendations to practicing oncologists and others on the management of brain …

The majority of metastatic colorectal cancers (mCRC) are mismatch repair (MMR) proficient
and unresponsive to immunotherapy, whereas MMR-deficient (MMRd) tumors often respond …

Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor and is
associated with a poor clinical prognosis. Despite the progress in the understanding of the …

Background Research on the sequencing of brain radiotherapy and targeted chemotherapy
after brain metastasis (BM) in HER2-positive breast cancer patients is limited and …

Glioblastoma is one of the most aggressive central nervous system malignancies with high
morbidity and mortality. Current clinical approaches, including surgical resection …