Abstract The Free Radical Theory of Ageing, was first proposed by Denham Harman in the
mid-1950's, based largely on work conducted by Rebeca Gerschman and Daniel Gilbert. At …

Bigger animals live longer. The scaling exponent for the relationship between lifespan and
body mass is between 0.15 and 0.3. Bigger animals also expend more energy, and the …

Abstract Naked mole rats (NMRs; Heterocephalus glaber) are the longest-living rodents
known, with a maximum lifespan of 30 years—5 times longer than expected on the basis of …

The choroid plexus (ChP) is a highly vascularized tissue found in the brain ventricles, with
an apical epithelial cell layer surrounding fenestrated capillaries. It is responsible for the …

Bone marrow stromal cells (BMSCs) and other cell populations derived from mesenchymal
precursors are developed for cell‐based therapeutic strategies and undergo cellular stress …

While the subject of environmental stress in animals is broad, the available information is
fragmentary and lacks an up-to-date overview and analysis. Environmental Stress and …

The focus of developmental biologists has expanded from the analysis of gene expression
to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate …

Aging is associated with loss of quality control in protein turnover. The ubiquitin-proteasome
pathway is critical to this quality control process as it degrades mutated and damaged …

Genetic analysis of Drosophila, mice and humans indicates that gene alleles, mutations and
transgenes that affect life span tend to do so differently depending on the sex of the …

Classical evolutionary theory predicts the existence of genes with antagonistic effects on
longevity and various components of early-life fitness. Quantitative genetic studies have …