Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

A common feature of cancer cells is their ability to rewire their metabolism to sustain the
production of ATP and macromolecules needed for cell growth, division and survival. In …

Metformin, traditionally regarded as a hypoglycemic drug, has been studied in other various
fields including inflammation. The specific mechanism of metformin's effect on immune cells …

Ovarian cancer is one of the most malignant gynecological cancers around the world. In
spite of multiple treatment options, the five-year survival rate is still very low. Several …

Ovarian cancer is the most malignant gynecological tumor. Previous studies have reported
that metabolic alterations resulting from deregulated lipid metabolism promote ovarian …

In cancerous cells, significant changes occur in the activity of signaling pathways affecting a
wide range of cellular activities ranging from growth and proliferation to apoptosis …

Metabolic alterations have been observed in many cancer types. The deregulated
metabolism has thus become an emerging hallmark of the disease, where the metabolism is …

Abstract Salt-inducible kinase 2 (SIK2) has been established as a regulator of diverse
biological processes including cell metabolism. A recent study has reported that SIK2 is …

Abstract Fatty Acid Synthase (FASN), a key enzyme of de novo lipogenesis, is upregulated
in many cancers including colorectal cancer (CRC); increased FASN expression is …

Altered lipid metabolism and aberrant protein translation are strongly associated with
cancerous outgrowth; however, the inter-regulation of these key processes is still …