Biomimetic synthesis of natural products: a journey to learn, to mimic, and to be better

R Bao, H Zhang, Y Tang - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Total synthesis of natural products has been one of the most exciting and
dynamic areas in synthetic organic chemistry. Nowadays, the major challenge in this field is …

[HTML][HTML] Marine compounds targeting the PI3K/Akt signaling pathway in cancer therapy

J Wei, Z Gou, Y Wen, Q Luo, Z Huang - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Cancer is a disease characterized by overproliferation, including that due to transformation,
apoptosis disorders, proliferation, invasion, angiogenesis and metastasis, and is one of the …

Marriage of peroxides and nitrogen heterocycles: selective three-component assembly, peroxide-preserving rearrangement, and stereoelectronic source of unusual …

IA Yaremenko, YY Belyakova, PS Radulov… - Journal of the …, 2021 - ACS Publications
Stable bridged azaozonides can be selectively assembled via a catalyst-free three-
component condensation of 1, 5-diketones, hydrogen peroxide, and an NH-group source …

Biogenetic and biomimetic synthesis of natural bisditerpenoids: hypothesis and practices

Y Chang, C Sun, C Wang, X Huo, W Zhao… - Natural Product …, 2022 - pubs.rsc.org
Covering: up to March 2022 Bisditerpenoids, or diterpenoid dimers, are a group of natural
products with high structural variance, deriving from homo-or hetero-dimeric coupling of two …

A soft spot for chemistry–current taxonomic and evolutionary implications of sponge secondary metabolite distribution

A Galitz, Y Nakao, PJ Schupp, G Wörheide… - Marine Drugs, 2021 - mdpi.com
Marine sponges are the most prolific marine sources for discovery of novel bioactive
compounds. Sponge secondary metabolites are sought-after for their potential in …

Enantioselective total syntheses of (+)-hippolachnin A,(+)-gracilioether A,(−)-gracilioether E, and (−)-gracilioether F

Q Li, K Zhao, A Peuronen, K Rissanen… - Journal of the …, 2018 - ACS Publications
The Plakortin polyketides represent a structurally and biologically fascinating class of marine
natural products. Herein, we report a unified strategy that enables the divergent syntheses of …

Benzylic Hydroperoxidation via Visible-Light-Induced Csp3–H Activation

J Inoa, M Patel, G Dominici, R Eldabagh… - The Journal of …, 2020 - ACS Publications
A highly efficient benzylic hydroperoxidation has been realized through a visible-light-
induced Csp3–H activation. We believe that this reaction undergoes a direct HAT …

Visible‐Light Photoredox Catalysis Enables the Biomimetic Synthesis of Nyingchinoids A, B, and D, and Rasumatranin D

JD Hart, L Burchill, AJ Day, CG Newton… - Angewandte …, 2019 - Wiley Online Library
The total synthesis of nyingchinoids A and B has been achieved through successive
rearrangements of a 1, 2‐dioxane intermediate that was assembled using a visible‐light …

Activation and Characterization of Bohemamine Biosynthetic Gene Cluster from Streptomyces sp. CB02009

L Liu, S Li, R Sun, X Qin, J Ju, C Zhang, Y Duan… - Organic …, 2020 - ACS Publications
Bohemamines (BHMs) are bacterial alkaloids containing a pyrrolizidine core with two
unusual methyl groups. Herein we report the activation of BHMs biosynthesis using a …

Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii

Y Wang, YC Liu, WY Li, K Guo, Y Liu, SH Li - Phytochemistry, 2021 - Elsevier
Abstract The Lamiaceae plant Ajuga forrestii Diels is a traditional Chinese herbal medicine
with abundant glandular trichomes (GTs), but their chemistry and biological functions remain …