Non-melanoma skin cancer, ie basal cell carcinoma (BCC) and squamous cell carcinoma
(SCC) are the most frequent tumors and their number is still increasing worldwide (1) …

MYC dysregulation initiates a dynamic process of genomic instability that is linked to tumor
initiation. Early studies using MYC-carrying retroviruses showed that these viruses were …

A‐type lamins are intermediate filament proteins that provide a scaffold for protein
complexes regulating nuclear structure and function. Mutations in the LMNA gene are linked …

Improving the spatial resolution of optical microscopes is important for a vast number of
applications in the life sciences. Optical microscopy allows intact samples and living cells to …

OBJECTIVE: Telomeres shorten and aggregate with cellular senescence and oxidative
stress. Telomerase and its catalytic component human telomerase reverse-transcriptase …

In previous work, we showed that telomeres of normal cells are organized within the 3D
space of the interphase nucleus in a nonoverlapping and cell cycle-dependent manner. This …

The mammalian genome is highly organized within the cell nucleus. The nuclear position of
many genes and genomic regions changes during physiological processes such as …

Background Quantitative analysis can be used in combination with fluorescence
microscopy. Although the human eye is able to obtain good qualitative results, when …

Ex vivo, human mesenchymal stem cells (hMSCs) undergo spontaneous cellular
senescence after a limited number of cell divisions. Intranuclear structures of the nuclear …

Telomerase-negative tumor cells maintain their telomeres via an alternative lengthening of
telomeres (ALT) mechanism. This process involves the association of telomeres with …