Regulation of placental development and its impact on fetal growth—new insights from mouse models

L Woods, V Perez-Garcia, M Hemberger - Frontiers in endocrinology, 2018 - frontiersin.org
The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …

Embryo–epithelium interactions during implantation at a glance

JD Aplin, PT Ruane - Journal of cell science, 2017 - journals.biologists.com
At implantation, with the acquisition of a receptive phenotype in the uterine epithelium, an
initial tenuous attachment of embryonic trophectoderm initiates reorganisation of epithelial …

Uterine luminal epithelium as the transient gateway for embryo implantation

X Ye - Trends in Endocrinology & Metabolism, 2020 - cell.com
The uterine luminal epithelium (LE) is the first maternal contact for an implanting embryo.
Intrauterine fluid resorption, cessation of LE proliferation and apoptosis, and LE structural …

Unraveling the Dynamics of Estrogen and Progesterone Signaling in the Endometrium: An Overview

ID Da Silva, V Wuidar, M Zielonka, C Pequeux - Cells, 2024 - pmc.ncbi.nlm.nih.gov
The endometrium is crucial for the perpetuation of human species. It is a complex and
dynamic tissue lining the inner wall of the uterus, regulated throughout a woman's life based …

The role of BMP4 signaling in trophoblast emergence from pluripotency

RM Roberts, T Ezashi, J Temple, JR Owen… - Cellular and Molecular …, 2022 - Springer
Abstract The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in
early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has …

The TGF-β family in the reproductive tract

D Monsivais, MM Matzuk… - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
The transforming growth factor β (TGF-β) family has a profound impact on the reproductive
function of various organisms. In this review, we discuss how highly conserved members of …

Uterine cyclin A2–deficient mice as a model of female early pregnancy loss

F Aljubran, K Schumacher, A Graham… - The Journal of Clinical …, 2024 - jci.org
Proper action of the female sex steroids 17β-estradiol (E2) and progesterone (P4) on the
endometrium is essential for fertility. Beyond its role in regulating the cell cycle, cyclin A2 …

TGFβ superfamily signaling and uterine decidualization

N Ni, Q Li - Reproductive biology and endocrinology, 2017 - Springer
Decidualization is an intricate biological process where extensive morphological, functional,
and genetic changes take place in endometrial stromal cells to support the development of …

Uterine glands impact uterine receptivity, luminal fluid homeostasis and blastocyst implantation

AM Kelleher, GW Burns, S Behura, G Wu… - Scientific reports, 2016 - nature.com
Uterine glands are essential for pregnancy in mice and likely humans, because they secrete
or transport bioactive substances that regulate uterine receptivity for blastocyst implantation …

Follistatin is critical for mouse uterine receptivity and decidualization

PT Fullerton Jr, D Monsivais… - Proceedings of the …, 2017 - National Acad Sciences
Embryo implantation remains a significant challenge for assisted reproductive technology,
with implantation failure occurring in∼ 50% of in vitro fertilization attempts. Understanding …