HLA-G: an immune checkpoint molecule

ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

HLA‐G: Function, polymorphisms and pathology

A Arnaiz‐Villena, I Juarez… - International Journal …, 2021 - Wiley Online Library
HLA‐G immune modulatory genes and molecules are presently being studied by a
widespread number of research groups. In the present study, we do not aim to be exhaustive …

Polymorphic Sites at the 3' Untranslated Region of the HLA-G Gene Are Associated with Differential hla-g Soluble Levels in the Brazilian and French Population

G Martelli-Palomino, JA Pancotto, YC Muniz… - PloS one, 2013 - journals.plos.org
HLA-G molecule has well-recognized tolerogenic properties, and the encoding gene shows
lower frequency of polymorphism at the coding region but higher variability at regulatory …

HLA-G molecules in autoimmune diseases and infections

R Rizzo, D Bortolotti, S Bolzani, E Fainardi - Frontiers in immunology, 2014 - frontiersin.org
Human leukocyte antigen (HLA)-G molecule, a non-classical HLA-Ib molecule, is less
polymorphic when compared to classical HLA class I molecules. Human leukocyte antigen …

Genetic association between HLA-G 14-bp polymorphism and diseases: A systematic review and meta-analysis

BS de Almeida, YCN Muniz, AH Prompt, EC Castelli… - Human immunology, 2018 - Elsevier
Background HLA-G is an immune checkpoint molecule. Since a differential molecule
expression has been reported even for healthy individuals, many studies have focused on …

The role of HLA-G in human papillomavirus infections and cervical carcinogenesis

HH Xu, WH Yan, A Lin - Frontiers in immunology, 2020 - frontiersin.org
Human leukocyte antigen (HLA)-G, a non-classical HLA-class I molecule, has a low
polymorphism frequency, restricted tissue distribution and immunoinhibitory property. HLA-G …

Human leukocyte antigen‐G in gynaecological tumours

X Guo, J Zhang, J Shang, Y Cheng… - International Journal …, 2023 - Wiley Online Library
Gynaecological tumours that threaten the health of women, especially when advanced and
recurrent, have remained mostly intractable to existing treatments. Therefore, new …

[HTML][HTML] Association of HLA-G Expression, Its Genetic Variants and Related Neuro-Immunomodulation with Characteristics of Bladder Carcinoma

V Durmanova, I Mikolaskova, E Zsemlye, A Ocenasova… - Cancers, 2024 - mdpi.com
Background: Human leukocyte antigen G (HLA-G) is an immune checkpoint molecule with
immunosuppressive and anti-inflammatory activities. It belongs to class I non-classical major …

[HTML][HTML] HLA-G-evolvement from a trophoblast specific marker to a checkpoint molecule in cancer, a narrative review about the specific role in breast-and …

J Knabl, Y Ye, G Desoye, U Jeschke - Journal of Reproductive Immunology, 2024 - Elsevier
Human leukocyte antigen G (HLA-G) is known as a non-classical molecule of the major
histocompatibility complex class Ib and downregulates the mother's immune response …

Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: a candidate molecule for therapeutic intervention and prognostic biomarker?

F Gimenes, JJV Teixeira, ALP de Abreu… - … et Biophysica Acta (BBA …, 2014 - Elsevier
While persistent infection with oncogenic types of human Papillomavirus (HPV) is required
for cervical epithelial cell transformation and cervical carcinogenesis, HPV infection alone is …