Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and
apoptosis by participating in multiple signaling pathways in the body. Studies have shown …

Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25%
one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

This Review focuses on the mechanistic evidence for a link between obesity, dysregulated
cellular metabolism and breast cancer. Strong evidence now links obesity with the …

Background Chemoresistance is a major factor contributing to the poor prognosis of patients
with pancreatic cancer, and cancer stemness is one of the most crucial factors associated …

Abstract" Life is an instantaneous encounter of circulating matter and flowing energy"(Jean
Giaja, Serbian physiologist), is one of the most elegant definitions not only of life but the …

Cell growth is regulated by the mammalian/mechanistic target of rapamycin complex 1
(mTORC1), which functions both as a nutrient sensor and a master controller of virtually all …

Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

African American (AA) women in the United States have a 40% higher breast cancer
mortality rate than Non-Hispanic White (NHW) women. The survival disparity is particularly …