Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Scars caused by skin injuries after burns, wounds, abrasions and operations have serious
physical and psychological effects on patients. In recent years, the research of scar free …

Inducing tissue regeneration in many skin defects, such as large traumatic wounds, burns,
other physicochemical wounds, bedsores, and chronic diabetic ulcers, has become an …

Injuries to our skin trigger a cascade of spatially-and temporally-synchronized healing
processes. During such endogenous wound repair, the role of fibroblasts is multifaceted …

Small animals do not replicate the severity of the human foreign-body response (FBR) to
implants. Here we show that the FBR can be driven by forces generated at the implant …

The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

Excessive reactive oxygen species (ROS) at severe burn injury sites may promote metabolic
reprogramming of macrophages to induce a deteriorative and uncontrolled inflammation …