The mitogen-activated protein kinase (MAPK) signaling pathway is the primary regulatory
module of various cellular processes such as cell proliferation, differentiation, and stress …

Cancer is one of the most common causes of death. So, its lethal effect increases with time.
Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or …

Lysosome‐targeting chimeras (LYTACs) are an emerging therapeutic modality that
effectively degrade cancer cell membranes and extracellular target proteins. In this study, a …

Finding an effective cure for Alzheimer's disease has eluded scientists despite intense
research. The disease is a cause of suffering for millions of people worldwide and is …

The Kirsten rat sarcoma oncoprotein (KRAS) has been punctuated by drug development
failures for decades due to frequent mutations that occur mostly at codon 12 and the …

Acute myeloid leukemia (AML) is a genetically extremely heterogeneous disease. Drug
resistance after induction therapy is a very frequent event resulting in poor medium survival …

Abstract Proteolysis Targeting Chimeras (PROTAC) technology has emerged as a promising
approach for targeted protein degradation. In this study, we focused on tyrosinase (TYR), a …

The first examples of ataxia telangiectasia and Rad3-related (ATR) PROTACs were
designed and synthesized. Among them, the most potent degrader, ZS-7, demonstrated …

Epithelial ovarian cancer (EOC) is associated with a dismal prognosis due to development
of resistance to chemotherapy and metastasis in the peritoneal cavity and distant organs. In …

Despite availability of several treatment options for non-small cell lung cancer (NSCLC),
such as surgery, chemotherapy, radiation, targeted therapy and immunotherapy, the survival …