Therapeutic applications of cell engineering using mRNA technology

Y He, APR Johnston, CW Pouton - Trends in Biotechnology, 2024 - cell.com
Engineering and reprogramming cells has significant therapeutic potential to treat a wide
range of diseases, by replacing missing or defective proteins, to provide transcription factors …

Analytical techniques for the characterization of nanoparticles for mRNA delivery

SS Nogueira, E Samaridou, J Simon, S Frank… - European Journal of …, 2024 - Elsevier
Nanotechnology-assisted RNA delivery has gotten a tremendous boost over the last decade
and made a significant impact in the development of life-changing vaccines and …

Development of an advanced separation and characterization platform for mRNA and lipid nanoparticles using multi-detector asymmetrical flow field-flow fractionation

Z Gao, J Lin, WC Su, K Zhang, J Gruenhagen… - Analytical and …, 2024 - Springer
In recent years, the use of lipid nanoparticles (LNPs) for delivery of messenger RNA (mRNA)–
based therapies has gained substantial attention in the field of drug development. In such an …

[HTML][HTML] Lipid nanoparticles for local delivery of mRNA to the respiratory tract: Effect of PEG-lipid content and administration route

M Ongun, AG Lokras, S Baghel, Z Shi… - European Journal of …, 2024 - Elsevier
Abstract Design of inhalable mRNA therapeutics is promising because local administration
in the respiratory tract is minimally invasive and induces a local response. However, several …

Stability indicating ion-pair reversed-phase liquid chromatography method for modified mRNA

J Currie, JR Dahlberg, E Lundberg, L Thunberg… - … of Pharmaceutical and …, 2024 - Elsevier
Modified messenger RNA (mRNA) represents a rapidly emerging class of therapeutic drug
product. Development of robust stability indicating methods for control of product quality are …

Anion exchange-HPLC method for evaluating the encapsulation efficiency of mRNA-loaded lipid nanoparticles using analytical quality by design

S Hara, S Arase, S Sano, T Suzuki, I Mizogaki… - … of Chromatography B, 2024 - Elsevier
Lipid nanoparticles (LNPs) are emerging nucleic acid delivery systems in the development
of mRNA therapeutics such as the severe acute respiratory syndrome coronavirus 2 …

Recent Advancements in Radiopharmaceuticals for Infection Imaging

E Dadachova, DEN Rangel - Intracellular Pathogens: Methods and …, 2024 - Springer
COVID-19 pandemic has heightened the interest toward diagnosis and treatment of
infectious diseases. Nuclear medicine, with its powerful scintigraphic, single photon …

RNA-Based Vaccines and Therapeutics Against Intracellular Pathogens

NS Kola, D Patel, A Thakur - Intracellular Pathogens: Methods and …, 2024 - Springer
RNA-based vaccines have sparked a paradigm shift in the treatment and prevention of
diseases by nucleic acid medicines. There has been a notable surge in the development of …

Advances in the polymeric nanoparticulate delivery systems for RNA therapeutics.

WH Almalki, R Karwasra, G Gupta, S Singh… - Progress in Molecular …, 2024 - europepmc.org
RNA therapeutics have emerged as potential treatments for genetic disorders, infectious
diseases, and cancer. RNA delivery to target cells for efficient therapeutic applications …

Developing an Outsource Driver Management Application to Improve Cargo Company Operational Efficiency

DJC Sihombing - Jurnal Ekonomi, 2024 - ejournal.seaninstitute.or.id
This research aims to develop an outsourced driver management application to improve the
operational efficiency of cargo companies. The methods include needs analysis, planning …