Historically, the use of mechanochemical methods in synthesis has been almost negligible,
but their perception by the synthetic community has changed in recent years and they are on …

Pyrrole is one of the most important one-ring heterocycles. The ready availability of suitably
substituted and functionalized pyrrole derivatives is essential for the progress of many …

Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

The review is devoted to modern trends in the chemistry of nitrogen-, oxygen-and sulfur-
containing monocyclic, polynuclear and benzo (hetero) annulated heterocyclic compounds …

Proline is a non‐toxic and inexpensive natural amino acid that is readily available in both
enantiomeric forms and was one of the very first compounds to be studied as an …

The α-ketoamide motif is widely found in many natural products and drug candidates with
relevant biological activities. Furthermore, α-ketoamides are attractive candidates to …

Controllable production of α‐keto amides and amides from the same substrates is an
attractive goal in the field of transition‐metal‐catalyzed (double‐) carbonylation. Herein, a …

Pyrroles are among the most privileged and influential small N-heterocycles at the core of
many commercial drugs, biological composition, natural compounds, agrochemicals, and …

The current manuscript describes the role and importance of catalysis and solvent effects for
the Biginelli multicomponent reaction. The overwhelming number of new catalysts and …

We review the most innovative efforts and greatest challenges faced when elucidating
multicomponent reactions (MCRs) mechanisms. When compared to traditional reactions, the …