Mesenchymal stem cell-derived exosomes: applications in regenerative medicine

MD Hade, CN Suire, Z Suo - Cells, 2021 - mdpi.com
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that
are then released into the extracellular space through a merging of the multivesicular body …

Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes

S Gurunathan, MH Kang, M Jeyaraj, M Qasim, JH Kim - Cells, 2019 - mdpi.com
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

Effects of mesenchymal stem cell-derived exosomes on autoimmune diseases

Z Shen, W Huang, J Liu, J Tian, S Wang… - Frontiers in …, 2021 - frontiersin.org
Recent years, the immunosuppressive properties of mesenchymal stem cells (MSCs) have
been demonstrated in preclinical studies and trials of inflammatory and autoimmune …

Emerging roles of exosomal miRNAs in diabetes mellitus

X He, G Kuang, Y Wu, C Ou - Clinical and translational …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by
almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids …

Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications

A Amiri, R Bagherifar, E Ansari Dezfouli… - Journal of Translational …, 2022 - Springer
Nanocarriers as drug/biomolecule delivery systems have been significantly developed
during recent decades. Given the stability, reasonable delivery efficiency, and safety of …

Extracellular vesicles: Emerging frontiers in wound healing

MD Hade, CN Suire, J Mossell… - Medicinal Research …, 2022 - Wiley Online Library
Extracellular vesicles are membranous particles, ranging from 30 nm to 10 µm in diameter,
which are released by nearly all cell types to aid in intercellular communication. These …

MSC exosome works through a protein-based mechanism of action

WS Toh, RC Lai, B Zhang, SK Lim - Biochemical Society …, 2018 - portlandpress.com
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …

Tissue-engineered bone immobilized with human adipose stem cells-derived exosomes promotes bone regeneration

W Li, Y Liu, P Zhang, Y Tang, M Zhou… - … applied materials & …, 2018 - ACS Publications
Exosomes, nanoscale extracellular vesicles functioning as cell-to-cell communicators, are
an emerging promising therapeutic in the field of bone tissue engineering. Here, we report …

Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer's disease model by increasing the expression of microRNA-146a in …

M Nakano, K Kubota, E Kobayashi, TS Chikenji… - Scientific reports, 2020 - nature.com
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau. We
previously reported that administration of bone marrow mesenchymal stem cells (BM-MSCs) …

MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment

WS Toh, RC Lai, JHP Hui, SK Lim - Seminars in cell & developmental …, 2017 - Elsevier
Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in
animal and clinical studies. The efficacy of MSC-based therapies which was previously …