Immune checkpoint blockade (ICB) therapy is a powerful option for cancer treatment.
Despite demonstrable progress, most patients fail to respond or achieve durable responses …

Chronic rhinosinusitis (CRS) is a chronic inflammatory condition of the nasal and paranasal
sinus mucosa that affects up to 10% of the population worldwide. CRS is the most …

Chronic rhinosinusitis (CRS), a common clinical condition characterized by persistent
mucosal inflammation and tissue remodeling, has a complex pathogenesis that is intricately …

Chronic rhinosinusitis is a chronic inflammatory disease of the upper airways, for which
treatment options include medical or surgical therapy. However, there are limitations to …

Chronic colonic inflammation is a feature of cancer and is strongly associated with
tumorigenesis, but its underlying molecular mechanisms remain poorly understood …

Chronic rhinosinusitis is a heterogenous and multifactorial disease, characterized by
persistent inflammation of the nose and paranasal sinuses, which causes nasal obstruction …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is caused by prolonged inflammation of
the paranasal sinus mucosa. The epithelial to mesenchymal transition (EMT) is involved in …

Background Diesel exhaust particles (DEPs) are associated with the prevalence and
exacerbation of allergic respiratory diseases, including allergic rhinitis and allergic asthma …

Neutrophils have traditionally been acknowledged as the first immune cells that are
recruited to inflamed tissues during acute inflammation. By contrast, their importance in the …

Background Previous studies have shown that epithelial-to-mesenchymal transition (EMT) in
nasal epithelial cells is critical for tissue remodeling of chronic rhinosinusitis with nasal …