At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs).
The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma …

Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell
surface proteins. GPIs in various organisms have a common backbone consisting of …

Fusion of myoblasts is essential for the formation of multi-nucleated muscle fibres. However,
the identity of muscle-specific proteins that directly govern this fusion process in mammals …

We show that amino acid covariation in proteins, extracted from the evolutionary sequence
record, can be used to fold transmembrane proteins. We use this technique to predict …

The prediction of the structures of proteins without detectable sequence similarity to any
protein of known structure remains an outstanding scientific challenge. Here we report …

Adiponectin receptors (ADIPORs) are integral membrane proteins that control glucose and
lipid metabolism by mediating, at least in part, a cellular ceramidase activity that catalyses …

The systemic RNAi-defective (SID) transmembrane family member 2 (SIDT2) is a putative
nucleic acid channel or transporter that plays essential roles in nucleic acid transport and …

Dear Editor, In the nematode Caenorhabditis elegans, the systemic RNA interference
defective protein 1 (SID-1) plays a crucial role in systemic RNA interference (RNAi) by …

Recent advances in protein structure prediction have generated accurate structures of
previously uncharacterized human proteins. Identifying domains in these predicted …

Membrane progesterone receptors (mPRs) are novel G protein-coupled receptors belonging
to the progestin and adipoQ receptor family (PAQR) that mediate a variety of rapid cell …