Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Diagnosis and management of lumbar spinal stenosis: a review

JN Katz, ZE Zimmerman, H Mass, MC Makhni - Jama, 2022 - jamanetwork.com
Importance Lumbar spinal stenosis is a prevalent and disabling cause of low back and leg
pain in older persons, affecting an estimated 103 million persons worldwide. Most are …

[HTML][HTML] Self-medication practices during the COVID-19 pandemic among the adult population in Peru: A cross-sectional survey

JF Quispe-Cañari, E Fidel-Rosales, D Manrique… - Saudi pharmaceutical …, 2021 - Elsevier
Self-medication impacts both negatively and positively the health of people, which has
become evident during the COVID-19 pandemic. The study aimed to assess the prevalence …

Emerging pharmaceutical therapies for osteoarthritis

A Latourte, M Kloppenburg, P Richette - Nature Reviews Rheumatology, 2020 - nature.com
The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …

[HTML][HTML] An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of …

O Bruyère, G Honvo, N Veronese, NK Arden… - Seminars in arthritis and …, 2019 - Elsevier
Abstract Objectives The European Society for Clinical and Economic Aspects of
Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) sought to revisit the …

2018 update of the EULAR recommendations for the management of hand osteoarthritis

M Kloppenburg, FPB Kroon, FJ Blanco… - Annals of the …, 2019 - ard.bmj.com
Since publication of the European League Against Rheumatism (EULAR) recommendations
for management of hand osteoarthritis (OA) in 2007 new evidence has emerged. The aim …

Cardiovascular effects and safety of (non-aspirin) NSAIDs

AM Schjerning, P McGettigan, G Gislason - Nature Reviews Cardiology, 2020 - nature.com
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective, widely used analgesics. For
the past 2 decades, considerable attention has been focused on their cardiovascular safety …

Long‐term adverse effects of paracetamol–a review

JC McCrae, EE Morrison, IM MacIntyre… - British journal of …, 2018 - Wiley Online Library
Paracetamol (acetaminophen) is the most commonly used drug in the world, with a long
record of use in acute and chronic pain. In recent years, the benefits of paracetamol use in …

Analgesic effect of acetaminophen: a review of known and novel mechanisms of action

N Ohashi, T Kohno - Frontiers in Pharmacology, 2020 - frontiersin.org
Acetaminophen is one of the most commonly used analgesic agents for treating acute and
chronic pain. However, its metabolism is complex, and its analgesic mechanisms have not …

[HTML][HTML] Type 2 diabetes mellitus and osteoarthritis

N Veronese, C Cooper, JY Reginster… - Seminars in arthritis and …, 2019 - Elsevier
Objectives Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are common diseases
that frequently co-exist, along with overweight/obesity. While the mechanical impact of …