Targeting MDMX for cancer therapy: rationale, strategies, and challenges
DH Yu, ZY Xu, S Mo, L Yuan, XD Cheng… - Frontiers in …, 2020 - frontiersin.org
The oncogene MDMX, also known as MDM4 is a critical negative regulator of the tumor
suppressor p53 and has been implicated in the initiation and progression of human cancers …
suppressor p53 and has been implicated in the initiation and progression of human cancers …
Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies
Glioblastoma (GB) is the most common and aggressive primary malignant astrocytoma
correlated with poor patient survival. There are no curative treatments for GB, and it …
correlated with poor patient survival. There are no curative treatments for GB, and it …
Adenosinergic pathway: a hope in the immunotherapy of glioblastoma
K Jin, C Mao, L Chen, L Wang, Y Liu, J Yuan - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor
with dismal survival and poor response to conventional therapies. Therefore, the …
with dismal survival and poor response to conventional therapies. Therefore, the …
Tumor cell and immune cell profiles in primary human glioblastoma: Impact on patient outcome
M González‐Tablas Pimenta, Á Otero… - Brain …, 2021 - Wiley Online Library
The distribution and role of tumor‐infiltrating leucocytes in glioblastoma (GBM) remain
largely unknown. Here, we investigated the cellular composition of 55 primary (adult) GBM …
largely unknown. Here, we investigated the cellular composition of 55 primary (adult) GBM …
Prognostic impact of PDGFRA gain/amplification and MGMT promoter methylation status in patients with IDH wild-type glioblastoma
N Higa, T Akahane, S Yokoyama… - Neuro-Oncology …, 2022 - academic.oup.com
Background Platelet-derived growth factor receptor alpha (PDGFRA) is the second most
frequently mutated tyrosine kinase receptor in glioblastoma (GBM). However, the prognostic …
frequently mutated tyrosine kinase receptor in glioblastoma (GBM). However, the prognostic …
Afatinib and radiotherapy, with or without temozolomide, in patients with newly diagnosed glioblastoma: results of a phase I trial
F Saran, L Welsh, A James, C McBain… - Journal of Neuro …, 2021 - Springer
Background Glioblastoma multiforme (GBM) is the most common primary malignant brain
tumor in adults. Amplification or overexpression of the epidermal growth factor receptor …
tumor in adults. Amplification or overexpression of the epidermal growth factor receptor …
A Potential Anti-Glioblastoma Compound LH20 Induces Apoptosis and Arrest of Human Glioblastoma Cells via CDK4/6 Inhibition
Y Wang, Y Li, D Liu, D Zheng, X Li, C Li, C Huang… - Molecules, 2023 - mdpi.com
Glioblastoma (GBM) is a deadly brain tumor characterized by signaling dysregulation and
aberrant cell cycle control. The CDK4/6-Rb axis is dysregulated in approximately 80% of all …
aberrant cell cycle control. The CDK4/6-Rb axis is dysregulated in approximately 80% of all …
Molecular alterations and their correlation with the survival of glioblastoma patients with corpus callosum involvement
M Cui, X Gao, Y Chi, M Zhang, H Lin, H Chen… - Frontiers in …, 2021 - frontiersin.org
Purpose: To explore molecular alterations and their correlation with the survival of patients
with glioblastoma (GBM) with corpus callosum (CC) involvement (ccGBM). Methods …
with glioblastoma (GBM) with corpus callosum (CC) involvement (ccGBM). Methods …
Involvement of PDGFR‐integrin interactions in the regulation of anoikis resistance in glioblastoma progression
P Pain, A Tripathi, PP Pillai - Cell Biology International, 2025 - Wiley Online Library
The interactions between platelet‐derived growth factor/PDGF receptor and integrin
signaling are crucial for cells to respond to extracellular stimuli. Integrin interactions with …
signaling are crucial for cells to respond to extracellular stimuli. Integrin interactions with …
Anoctamins and Calcium Signalling: An Obstacle to EGFR Targeted Therapy in Glioblastoma?
Simple Summary Glioblastoma is the most lethal form of brain cancer in adults. No new
successful treatments have been developed in 30 years and survival rates have not …
successful treatments have been developed in 30 years and survival rates have not …