Size-based separation methods of circulating tumor cells

SJ Hao, Y Wan, YQ Xia, X Zou, SY Zheng - Advanced drug delivery reviews, 2018 - Elsevier
Circulating tumor cells (CTCs) originate from the primary tumor mass and enter into the
peripheral bloodstream. Compared to other “liquid biopsy” portfolios such as exosome …

Bioprinting of thermoresponsive hydrogels for next generation tissue engineering: a review

R Suntornnond, J An, CK Chua - Macromolecular Materials and …, 2017 - Wiley Online Library
Bioprinting is a breakthrough technology that integrates living cells, biomaterials, and a
robotic dispensing system to create complex structures that mimic original tissues and …

Association of circulating tumor DNA and circulating tumor cells after neoadjuvant chemotherapy with disease recurrence in patients with triple-negative breast cancer …

M Radovich, G Jiang, BA Hancock, C Chitambar… - JAMA …, 2020 - jamanetwork.com
Importance A significant proportion of patients with early-stage triple-negative breast cancer
(TNBC) are treated with neoadjuvant chemotherapy. Sequencing of circulating tumor DNA …

Isolation of circulating tumor cells in non-small-cell-lung-cancer patients using a multi-flow microfluidic channel

J Zhou, A Kulasinghe, A Bogseth, K O'Byrne… - Microsystems & …, 2019 - nature.com
Circulating tumor cells (CTCs) carry a wealth of information on primary and metastatic
tumors critical for precise cancer detection, monitoring, and treatment. Numerous …

Biochemical analysis on microfluidic chips

J Wu, Z He, Q Chen, JM Lin - TrAC Trends in Analytical Chemistry, 2016 - Elsevier
Biochemical analysis is crucial in understanding mechanism of life activities and giving
biological insights into life process. With inherent merits in flexible design, microscale of …

High-throughput isolation of circulating tumor cells using cascaded inertial focusing microfluidic channel

A Abdulla, W Liu, A Gholamipour-Shirazi… - Analytical …, 2018 - ACS Publications
Circulating tumor cells (CTCs) are rare cells that detach from a primary or metastasis tumor
and flow into the bloodstream. Intact and viable tumor cells are needed for genetic …

Recent advances in microfluidic platform for physical and immunological detection and capture of circulating tumor cells

MP Bhat, V Thendral, UT Uthappa, KH Lee, M Kigga… - Biosensors, 2022 - mdpi.com
CTCs (circulating tumor cells) are well-known for their use in clinical trials for tumor
diagnosis. Capturing and isolating these CTCs from whole blood samples has enormous …

Latest advances and perspectives of liquid biopsy for cancer diagnostics driven by microfluidic on-chip assays

Y Xie, X Xu, J Wang, J Lin, Y Ren, A Wu - Lab on a Chip, 2023 - pubs.rsc.org
Microfluidic-based lab-on-a-chip technology is a multidisciplinary approach, which has
evolved rapidly in the past decade and remains a hot research topic as a promising …

Liquid biopsy in pancreatic ductal adenocarcinoma: current status of circulating tumor cells and circulating tumor DNA

JS Lee, SS Park, YK Lee, JA Norton… - Molecular …, 2019 - Wiley Online Library
Reliable biomarkers are required to evaluate and manage pancreatic ductal
adenocarcinoma. Circulating tumor cells and circulating tumor DNA are shed into blood and …

High-purity capture of CTCs based on micro-beads enhanced isolation by size of epithelial tumor cells (ISET) method

N Sun, X Li, Z Wang, Y Li, R Pei - Biosensors and Bioelectronics, 2018 - Elsevier
In this paper, we develop a low-cost size-based microfluidic chip using conventional
polycarbonate membrane to isolate CTCs from blood, and propose a strategy to increase …