18F Labeling of Arenes

M Tredwell, V Gouverneur - Angewandte Chemie International …, 2012 - Wiley Online Library
Molecular imaging has witnessed an upsurge in growth, with positron emission tomography
leading the way. This trend has encouraged numerous synthetic chemists to enter the field …

18F‐Labeling of Sensitive Biomolecules for Positron Emission Tomography

HS Krishnan, L Ma, N Vasdev… - Chemistry–A European …, 2017 - Wiley Online Library
Positron emission tomography (PET) imaging study of fluorine‐18 labeled biomolecules is
an emerging and rapidly growing area for preclinical and clinical research. The present …

Micro-chemical synthesis of molecular probes on an electronic microfluidic device

PY Keng, S Chen, H Ding, S Sadeghi… - Proceedings of the …, 2012 - National Acad Sciences
We have developed an all-electronic digital microfluidic device for microscale chemical
synthesis in organic solvents, operated by electrowetting-on-dielectric (EWOD). As an …

Microfluidics in radiopharmaceutical chemistry

G Pascali, P Watts, PA Salvadori - Nuclear medicine and biology, 2013 - Elsevier
The increased demand for molecular imaging tracers useful in assessing and monitoring
diseases has stimulated research towards more efficient and flexible radiosynthetic routes …

Microfluidics: a groundbreaking technology for PET tracer production?

C Rensch, A Jackson, S Lindner, R Salvamoser… - Molecules, 2013 - mdpi.com
Application of microfluidics to Positron Emission Tomography (PET) tracer synthesis has
attracted increasing interest within the last decade. The technical advantages of …

State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis

LYF Haveman, DJ Vugts, AD Windhorst - EJNMMI Radiopharmacy and …, 2023 - Springer
Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and
clinical nuclear imaging technique used in disease diagnosis and therapy assessment …

Production of [11C]Carbon Labelled Flumazenil and L-Deprenyl Using the iMiDEV™ Automated Microfluidic Radiosynthesizer

H Mallapura, L Tanguy, B Långström, LL Meunier… - Molecules, 2022 - mdpi.com
In the last decade, microfluidic techniques have been explored in radiochemistry, and some
of them have been implemented in preclinical production. However, these are not suitable …

18F-AlF Labeled Peptide and Protein Conjugates as Positron Emission Tomography Imaging Pharmaceuticals

K Kumar, A Ghosh - Bioconjugate chemistry, 2018 - ACS Publications
The clinical applications of positron emission tomography (PET) imaging pharmaceuticals
have increased tremendously over the past several years since the approval of 18fluorine …

Digital microfluidics: a new paradigm for radiochemistry

PY Keng, RM van Dam - Molecular imaging, 2015 - journals.sagepub.com
The emerging technology of digital microfluidics is opening up the possibility of performing
radiochemistry at the microliter scale to produce tracers for positron emission tomography …

Ultra-compact, automated microdroplet radiosynthesizer

J Wang, PH Chao, RM van Dam - Lab on a Chip, 2019 - pubs.rsc.org
Application of microfluidics offers numerous advantages in the field of radiochemistry and
could enable dramatic reductions in the cost of producing radiotracers for positron emission …