The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions
Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
Biology of poly (ADP-ribose) polymerases: the factotums of cell maintenance
P Bai - Molecular cell, 2015 - cell.com
The protein family of poly (ADP-ribose) polymerases (PARPs) or diphtheria toxin-type ADP-
ribose transferases (ARTDs) are multidomain proteins originally identified as DNA repair …
ribose transferases (ARTDs) are multidomain proteins originally identified as DNA repair …
Updated protein domain annotation of the PARP protein family sheds new light on biological function
MJ Suskiewicz, D Munnur, Ø Strømland… - Nucleic Acids …, 2023 - academic.oup.com
AlphaFold2 and related computational tools have greatly aided studies of structural biology
through their ability to accurately predict protein structures. In the present work, we explored …
through their ability to accurately predict protein structures. In the present work, we explored …
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
Despite the global impact of macrophage activation in vascular disease, the underlying
mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage …
mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage …
The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1
A Dhoonmoon, CM Nicolae, GL Moldovan - Nature communications, 2022 - nature.com
Suppression of nascent DNA degradation has emerged as an essential role of the BRCA
pathway in genome protection. In BRCA-deficient cells, the MRE11 nuclease is responsible …
pathway in genome protection. In BRCA-deficient cells, the MRE11 nuclease is responsible …
PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis
ADP-ribosylation (ADPRylation) is a posttranslational modification of proteins discovered
nearly six decades ago, but many important questions remain regarding its molecular …
nearly six decades ago, but many important questions remain regarding its molecular …
Beyond thrombosis: the impact of tissue factor signaling in cancer
D Unruh, C Horbinski - Journal of hematology & oncology, 2020 - Springer
Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend
well beyond hemostasis. When TF binds to Factor VII, the resulting TF: FVIIa complex can …
well beyond hemostasis. When TF binds to Factor VII, the resulting TF: FVIIa complex can …
The role of PARPs in inflammation—and metabolic—related diseases: molecular mechanisms and beyond
Y Ke, C Wang, J Zhang, X Zhong, R Wang, X Zeng… - Cells, 2019 - mdpi.com
Poly (ADP-ribosyl) ation (PARylation) is an essential post-translational modification
catalyzed by poly (ADP-ribose) polymerase (PARP) enzymes. Poly (ADP-ribose) …
catalyzed by poly (ADP-ribose) polymerase (PARP) enzymes. Poly (ADP-ribose) …
Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory …
The FANTOM5 consortium utilised cap analysis of gene expression (CAGE) to provide an
unprecedented insight into transcriptional regulation in human cells and tissues. In the …
unprecedented insight into transcriptional regulation in human cells and tissues. In the …
A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages
TB Huffaker, HA Ekiz, C Barba, SH Lee… - Nature …, 2021 - nature.com
Tumor associated macrophage responses are regulated by distinct metabolic states that
affect their function. However, the ability of specific signals in the local tumor …
affect their function. However, the ability of specific signals in the local tumor …