1. General Introduction 2. An Introduction to Ion Channels (a) General properties of ion
channels (i) Fundamental properties (ii) Planar bilayer electrophysiology (iii) Physiological …

Ion channels control the flux of ions across lipid bilayers in an extremely sensitive and
specific manner. From a description of selective permeability (Bernstein, 1912), made more …

NATURALLY occurring membrane channels and pores are formed from a large family of
diverse proteins, peptides and organic secon-dary metabolites whose vital biological …

THE extent of degradation of natural organic mixtures largely determines their utility as
records of depositional history, and their potential to act as nutritional substrates and fossil …

Bcl-2 is the prototypical member of a large family of apoptosis-regulating proteins, consisting
of blockers and promoters of cell death. The three-dimensional structure of a Bcl-2 …

Polypeptides composed of 30 amino acid residues or less typically do not adoptwell-defined
conformations in aqueous solution; rather they adopt an ensemble of energetically similar …

Integral membrane proteins have recently been shown to recognize and interact with other
proteins within the membrane, either mimicking or altering their function, and with the lipid …

Ligand-gated ion channels mediate the rapid action of neurotransmitters at the synapse. In a
matter of microseconds after release from the nerve terminal, neurotransmitter finds these …

We describe an efficient regiospecific method for cyclization of unprotected peptide
segments based on intramolecular transthioesterification of unprotected cysteinyl peptide …

We have recently adopted a “minimalist” approach to protein design. 1 As applied to the
analysis of natural proteins, this approach involves two steps: first, the structural basis for a …