Hair follicle immune privilege and its collapse in alopecia areata

M Bertolini, K McElwee, A Gilhar… - Experimental …, 2020 - Wiley Online Library
Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge
downwards to the bulb. Both passive and active IP mechanisms protect HFs from …

Engineered antigen-specific regulatory T cells for autoimmune skin conditions

Z Mukhatayev, YO Ostapchuk, D Fang, IC Le Poole - Autoimmunity reviews, 2021 - Elsevier
Regulatory T cells (Tregs) are a subset of T cells responsible for the regulation of immune
responses, thereby maintaining immune homeostasis and providing immune tolerance to …

Diverse role of OX40 on T cells as a therapeutic target for skin diseases

H Iriki, H Takahashi, M Amagai - Journal of Investigative Dermatology, 2023 - Elsevier
OX40 is an important costimulatory molecule for T-cell expansion and survival. Because
OX40 is expressed on most T-cell subsets, it is an attractive therapeutic target for a variety of …

[HTML][HTML] Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy

X Lin, X Meng, Z Song - American journal of translational research, 2019 - ncbi.nlm.nih.gov
Alopecia areata is characterized by the loss of hair on the scalp and elsewhere on the body.
It affects approximately 2% of the general population. It is believed to be an autoimmune …

Immune cell regulation of the hair cycle

ECE Wang, CA Higgins - Experimental dermatology, 2020 - Wiley Online Library
The ability to manipulate the mammalian hair cycle will lead to novel therapies and
strategies to combat all forms of alopecia. Thus, in addition to the epithelial‐mesenchymal …

Alopecia areata: recent advances and emerging therapies

J Seneschal, K Boniface, C Jacquemin - Annales de Dermatologie et de …, 2022 - Elsevier
Alopecia areata is an acquired, chronic, non-scarring hair disorder of the skin affecting 0.5-
2% of the general population worldwide. Multiple mechanisms are involved in the disease …

[HTML][HTML] A transcriptomic map of murine and human alopecia areata

N Borcherding, SB Crotts, LS Ortolan, N Henderson… - JCI insight, 2020 - ncbi.nlm.nih.gov
Alopecia areata (AA) is a common autoimmune condition, presenting initially with loss of
hair without other overt skin changes. The unremarkable appearance of the skin surface …

Functional interrogation of lymphocyte subsets in alopecia areata using single-cell RNA sequencing

EY Lee, Z Dai, A Jaiswal, EHC Wang… - Proceedings of the …, 2023 - National Acad Sciences
Alopecia areata (AA) is among the most prevalent autoimmune diseases, but the
development of innovative therapeutic strategies has lagged due to an incomplete …

Evaluation of platelet-rich plasma on hair regrowth and lesional T-cell cytokine expression in alopecia areata: a randomized observer-blinded, placebo-controlled …

V Gupta, AS Parihar, VK Sharma, S Jain… - Journal of the American …, 2021 - Elsevier
Background Platelet-rich plasma has shown some promise in the treatment of alopecia
areata. Objective To evaluate the effect of platelet-rich plasma on hair regrowth and lesional …

Topical metformin as a novel therapy for alopecia areata due to its immunologic effects

P Kokhabi, S Dadkhahfar, RM Robati - Medical Hypotheses, 2023 - Elsevier
Alopecia areata (AA) is an autoimmune and inflammatory hair follicle disorder.
Environmental and inherited factors may both contribute to this condition. Numerous studies …