Wnt signalling regulates several cellular functions including proliferation, differentiation,
apoptosis and migration, and is critical for embryonic development. Stem cells are defined …

Prognosis of gastric cancer is dramatically improved by early diagnosis. Correa's cascade
correlates the expression of some molecular markers with the progression of preneoplastic …

Purpose: The incidence rates of colorectal cancers are increasing in young adults. The
objective of this study was to investigate genomic differences between tumor samples …

Intestinal-type gastric carcinoma exhibits a multistep carcinogenic sequence from adenoma
to carcinoma with a gradual increase in genomic alterations. But the roles of microRNAs …

Purpose: Gene fusions involving R-spondin (RSPOfp) and RNF43 mutations have been
shown to drive Wnt-dependent tumor initiation in colorectal cancer. Herein, we aimed to …

Gastric cancer (GC) is one of the leading causes of cancer related mortality in the world.
Being asymptomatic in nature till advanced stage, diagnosis of gastric cancer becomes …

Checkpoint inhibitor approval for microsatellite instability-high (MSI-H) tumours has made
MSI as a therapeutically important biomarker. Next-generation sequencing (NGS)-based …

Cancer-associated RNF43 mutations lead to activation of β-catenin signaling through
aberrantly increasing Wnt-receptor levels at the membrane. Importantly, inactivating RNF43 …

This paper deals with Internet of Things (IoT) data analytics in a collaborative platform where
computing resources are available both at the network edge and at the backend cloud …

Background & Aims RING finger protein 43 (RNF43) is a tumor suppressor that frequently is
mutated in gastric tumors. The link between RNF43 and modulation of Wingless-related …