Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …

When considering the control of gene expression, the focus has traditionally been on
transcriptional regulation. Recently, however, the large contribution made by mRNA decay …

The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm
of virally infected cells is largely unknown. We demonstrated that the 5′-triphosphate end of …

The DNA damage‐dependent poly (ADP‐ribose) polymerases, PARP‐1 and PARP‐2, homo‐
and heterodimerize and are both involved in the base excision repair (BER) pathway. Here …

Interferon-induced proteins with tetratricopeptide repeats (IFITs) are innate immune effector
molecules that are thought to confer antiviral defence through disruption of protein–protein …

Transfer RNAs (tRNAs) decode messenger RNA codons to peptides at the ribosome. The
nuclear genome contains many tRNA genes for each amino acid and even each anticodon …

Transfer RNAs (tRNAs) are essential for protein synthesis. In eukaryotes, tRNA biosynthesis
employs a specialized RNA polymerase that generates initial transcripts that must be …

1Department of Biochemistry and Molecular Biology, Pennsylvania State University College
of Medicine, Hershey, Pennsylvania 17033, USA; 2Department of Biochemistry and …

Chromosome stability requires a dynamic balance of DNA loss and gain in each terminal
tract of telomeric repeats. Repeat addition by a specialized reverse transcriptase …

Nuclear ribonuclease (RNase) P is a ubiquitous essential ribonucleoprotein complex, one of
only two known RNA-based enzymes found in all three domains of life. The RNA component …