Olfaction in Parkinson's disease and related disorders

RL Doty - Neurobiology of disease, 2012 - Elsevier
Olfactory dysfunction is an early 'pre-clinical'sign of Parkinson's disease (PD). The present
review is a comprehensive and up-to-date assessment of such dysfunction in PD and …

Epidemiology of Parkinson's disease

CM Tanner, SM Goldman - Neurologic clinics, 2005 - pmc.ncbi.nlm.nih.gov
Parkinson's diseuse, a disorder of unknown cause, is a distinct clinical and neuropathologic
entity, characterized clinically by bradykinesia, resting tremor, cogwheel rigidity, and …

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

MH Polymeropoulos, JJ Higgins, LI Golbe… - Science, 1996 - science.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, affecting approximately 1 percent of the population over age 50 …

Genetic and environmental factors in the cause of Parkinson's disease

TT Warner, AHV Schapira - … of Neurology: Official Journal of the …, 2003 - Wiley Online Library
Despite being the subject of intense study, the pathogenesis of Parkinson's disease still
remains unclear. In recent years, however, there has been increasing evidence to support a …

Olfactory dysfunction in Parkinson's disease.

CH Hawkes, BC Shephard, SE Daniel - Journal of Neurology …, 1997 - jnnp.bmj.com
OBJECTIVE: To evaluate olfactory function in Parkinson's disease. METHODS: A
standardised odour identification test was used, together with an evoked potential …

Possible environmental, occupational, and other etiologic factors for Parkinson's disease: a case‐control study in Germany

A Seidler, W Hellenbrand, BP Robra, P Vieregge… - Neurology, 1996 - AAN Enterprises
In a case-control study, we investigated the possible etiologic relevance to Parkinson's
disease (PD) of rural factors such as farming activity, pesticide exposures, well-water …

Polymorphism in serotonin transporter gene associated with susceptibility to major depression

AD Ogilvie, S Battersby, G Fink, AJ Harmar… - The Lancet, 1996 - thelancet.com
Background The serotonin transporter of the brain provides the primary target for the action
of selective antidepressant drugs. We set out to identify polymorphisms of the serotonin …

Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema

CAD Smith, DJ Harrison - The Lancet, 1997 - thelancet.com
Background The first-pass metabolism of foreign compounds in the lung is an important
protective mechanism against oxidative stress. We investigated whether polymorphisms in …

Gene–environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models

JR Cannon, JT Greenamyre - Neurobiology of disease, 2013 - Elsevier
Interactions between genetic factors and environmental exposures are thought to be major
contributors to the etiology of Parkinson's disease. While such interactions are poorly …

Thermolabile variant of 5, 10-methylenetetrahydrofolate reductaseassociated with low red-cell folates: implications for folate intake recommendations

AM Molloy, S Daly, JL Mills, PN Kirke, AS Whitehead… - The Lancet, 1997 - thelancet.com
Background The dietary reference values for folate, as for other nutrients, are targeted to the
general and supposedly normal population, not people with special needs, such as those …