Guanine nucleotide–binding proteins regulate a variety of processes, including sensual
perception, protein synthesis, various transport processes, and cell growth and …

The high-resolution structures of ribosomal subunits published in 2000 have revolutionized
the field of protein translation. They facilitated the determination and interpretation of …

The large ribosomal subunit catalyzes peptide bond formation and binds initiation,
termination, and elongation factors. We have determined the crystal structure of the large …

The 30S ribosomal subunit has two primary functions in protein synthesis. It discriminates
against aminoacyl transfer RNAs that do not match the codon of messenger RNA, thereby …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

The publication of crystal structures of the 50S and 30S ribosomal subunits and the intact
70S ribosome is revolutionizing our understanding of protein synthesis. This review is an …

We describe two structures of the intact bacterial ribosome from Escherichia coli determined
to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed …

GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …

The small ribosomal subunit performs the decoding of genetic information during translation.
The structure of that from Thermus thermophilus shows that the decoding center, which …

The ribosome is a macromolecular assembly that is responsible for protein biosynthesis
following genetic instructions in all organisms. It is composed of two unequal subunits: the …