Structural determinants of ivabradine block of the open pore of HCN4
A Saponaro, JH Krumbach, A Chaves-Sanjuan… - Proceedings of the …, 2024 - pnas.org
HCN1-4 channels are the molecular determinants of the If/Ih current that crucially regulates
cardiac and neuronal cell excitability. HCN dysfunctions lead to sinoatrial block (HCN4) …
cardiac and neuronal cell excitability. HCN dysfunctions lead to sinoatrial block (HCN4) …
Different fluorescent labels report distinct components of spHCN channel voltage sensor movement
MN Wojciechowski, CE McKenzie, A Hung… - Journal of General …, 2024 - rupress.org
We used voltage clamp fluorometry to probe the movement of the S4 helix in the voltage-
sensing domain of the sea urchin HCN channel (spHCN) expressed in Xenopus oocytes …
sensing domain of the sea urchin HCN channel (spHCN) expressed in Xenopus oocytes …
Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution
K Benndorf, U Enke, D Tewari, J Kusch, H Liu, H Sun… - bioRxiv, 2024 - biorxiv.org
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that
generate rhythmic electrical activity in neuronal and cardiac pacemaker cells. The channels …
generate rhythmic electrical activity in neuronal and cardiac pacemaker cells. The channels …
Disruption of Ordered Membrane Domains as a Mechanism Underlying Neuropathic Pain
LJ Handlin, NL Macchi, N Dumaire, L Salih… - bioRxiv, 2023 - biorxiv.org
Cell membranes consist of heterogeneous lipid domains that influence key cellular
processes, including signal transduction, endocytosis, and electrical excitability. The goal of …
processes, including signal transduction, endocytosis, and electrical excitability. The goal of …