Lipoprotein (a) and cardiovascular disease

PR Kamstrup - Clinical chemistry, 2021 - academic.oup.com
Background High lipoprotein (a) concentrations present in 10%–20% of the population have
long been linked to increased risk of ischemic cardiovascular disease. It is unclear whether …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

Antisense oligonucleotides targeting apolipoprotein (a) in people with raised lipoprotein (a): two randomised, double-blind, placebo-controlled, dose-ranging trials

NJ Viney, JC van Capelleveen, RS Geary, S Xia… - The Lancet, 2016 - thelancet.com
Summary Background Elevated lipoprotein (a)(Lp [a]) is a highly prevalent (around 20% of
people) genetic risk factor for cardiovascular disease and calcific aortic valve stenosis, but …

[HTML][HTML] The role of lipids and lipoproteins in atherosclerosis

MRF Linton, PG Yancey, SS Davies, WG Jerome… - Endotext …, 2019 - ncbi.nlm.nih.gov
Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …

Lipoprotein (a) levels and the risk of myocardial infarction among 7 ethnic groups

G Paré, A Çaku, M McQueen, SS Anand, E Enas… - Circulation, 2019 - Am Heart Assoc
Background: Lipoprotein (a)[Lp (a)] levels predict the risk of myocardial infarction (MI) in
populations of European ancestry; however, few data are available for other ethnic groups …

Aspirin for primary prevention of cardiovascular events in relation to lipoprotein (a) genotypes

P Lacaze, A Bakshi, M Riaz, G Polekhina… - Journal of the American …, 2022 - jacc.org
Background The role of aspirin in reducing lipoprotein (a)-mediated atherothrombotic events
in primary prevention is not established. Objectives This study sought to assess whether low …

Antisense therapy targeting apolipoprotein (a): a randomised, double-blind, placebo-controlled phase 1 study

S Tsimikas, NJ Viney, SG Hughes, W Singleton… - The Lancet, 2015 - thelancet.com
Summary Background Lipoprotein (a)(Lp [a]) is a risk factor for cardiovascular disease and
calcific aortic valve stenosis. No effective therapies to lower plasma Lp (a) concentrations …

Lipoprotein (a) as a cardiovascular risk factor: current status

BG Nordestgaard, MJ Chapman, K Ray… - European heart …, 2010 - academic.oup.com
Aims The aims of the study were, first, to critically evaluate lipoprotein (a)[Lp (a)] as a
cardiovascular risk factor and, second, to advise on screening for elevated plasma Lp (a), on …

Lipoprotein (a): resurrected by genetics

F Kronenberg, G Utermann - Journal of internal medicine, 2013 - Wiley Online Library
Plasma lipoprotein (a)[L p (a)] is a quantitative genetic trait with a very broad and skewed
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …