The hypocretins/orexins: integrators of multiple physiological functions

J Li, Z Hu, L de Lecea - British journal of pharmacology, 2014 - Wiley Online Library
The hypocretins (H crts), also known as orexins, are two peptides derived from a single
precursor produced in the posterior lateral hypothalamus. Over the past decade, the orexin …

The role of NPY in hypothalamic mediated food intake

RE Mercer, MJS Chee, WF Colmers - Frontiers in neuroendocrinology, 2011 - Elsevier
Neuropeptide Y (NPY) is a highly conserved neuropeptide with orexigenic actions in
discrete hypothalamic nuclei that plays a role in regulating energy homeostasis. NPY …

[HTML][HTML] Sleep-wake and arousal dysfunctions in post-traumatic stress disorder: Role of orexin systems

GB Kaplan, GA Lakis, H Zhoba - Brain Research Bulletin, 2022 - Elsevier
Post-traumatic stress disorder (PTSD) is a trauma-related condition that produces
distressing fear memory intrusions, avoidance behaviors, hyperarousal/startle, stress …

[HTML][HTML] Natural products as safeguards against monosodium glutamate-induced toxicity

MM Hajihasani, V Soheili, MR Zirak… - Iranian Journal of …, 2020 - ncbi.nlm.nih.gov
Monosodium glutamate is a sodium salt of a nonessential amino acid, L-glutamic acid,
which is widely used in food industry. Glutamate plays an important role in principal brain …

Genotoxicity of monosodium glutamate

N Ataseven, D Yüzbaşıoğlu, AÇ Keskin… - Food and Chemical …, 2016 - Elsevier
Monosodium glutamate (MSG) is one of the most widely used flavor enhancers throughout
the world. The aim of this study is to investigate the genotoxic potential of MSG by using …

[HTML][HTML] Disruptive consequences of monosodium glutamate on male reproductive function: A review

DT Oluwole, OS Ebiwonjumi, LO Ajayi, OD Alabi… - Current Research in …, 2024 - Elsevier
Monosodium glutamate (MSG) is one of the most extensively used flavour enhancers
worldwide. Although it is widely regarded as a safe food additive with no recommended …

[HTML][HTML] Monosodium glutamate induced testicular lesions in rats (histological study)

AD Alalwani - Middle East Fertility Society Journal, 2014 - Elsevier
Objective Monosodium glutamate (MSG) commonly consumed as a flavor enhancer and
food additive in most soup, salad, and processed meat. The present study was designed to …

Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls

JW Yeoh, EJ Campbell, MH James… - Frontiers in …, 2014 - frontiersin.org
The tight regulation of sleep/wake states is critical for mental and physiological wellbeing.
For example, dysregulation of sleep/wake systems predisposes individuals to metabolic …

Orexin activation precedes increased NPY expression, hyperphagia, and metabolic changes in response to sleep deprivation

PJF Martins, MS Marques, S Tufik… - American Journal of …, 2010 - journals.physiology.org
Several pieces of evidence support that sleep duration plays a role in body weight control.
Nevertheless, it has been assumed that, after the identification of orexins (hypocretins), the …

Corticosterone regulates synaptic input organization of POMC and NPY/AgRP neurons in adult mice

E Gyengesi, ZW Liu, G D'Agostino, G Gan… - …, 2010 - academic.oup.com
Changes in circulating hormones, such as leptin and ghrelin, induce alterations in synaptic
input organization and electrophysiological properties of neurons of the arcuate nucleus of …