Therapeutic potential of certain terpenoids as anticancer agents: a scoping review

S Kamran, A Sinniah, MAM Abdulghani, MA Alshawsh - Cancers, 2022 - mdpi.com
Simple Summary Terpenoids are bioactive compounds with a variety of pharmacological
activities, including anticancer activity. This review paper aimed to focus on the anticancer …

Molecular pharmacology and therapeutic advances of the pentacyclic triterpene lupeol

AAM Sohag, MT Hossain, MA Rahaman, P Rahman… - Phytomedicine, 2022 - Elsevier
Background Plant triterpenoids are major sources of nutraceuticals that provide many health
benefits to humans. Lupeol is one of the pentacyclic dietary triterpenoids commonly found in …

Lupeol, a pentacyclic triterpene, promotes migration, wound closure, and contractile effect in vitro: Possible involvement of PI3K/Akt and p38/ERK/MAPK pathways

F Pereira Beserra, M Xue, GLA Maia, A Leite Rozza… - Molecules, 2018 - mdpi.com
Skin wound healing is a dynamic and complex process involving several mediators at the
cellular and molecular levels. Lupeol, a phytoconstituent belonging to the triterpenes class …

Suppression of EGFR/STAT3 activity by lupeol contributes to the induction of the apoptosis of human non-small cell lung cancer cells

TR Min, HJ Park, KT Ha, GY Chi… - … journal of oncology, 2019 - spandidos-publications.com
The aim of this study was to investigate the underlying mechanisms responsible for the
anticancer effects of lupeol on human non-small cell lung cancer (NSCLC). MTT assay and …

Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer

D Saha, D Mitra, N Alam, S Sen, SM Mustafi… - Journal of Cell …, 2023 - Springer
Vasculogenic mimicry (VM), defined as an endothelial cell independent alternative
mechanism of blood and nutrient supply by dysregulated tumor cells, is associated with poor …

Ex vivo culture models to indicate therapy response in head and neck squamous cell carcinoma

I Demers, J Donkers, B Kremer, EJ Speel - Cells, 2020 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is characterized by a poor 5 year
survival and varying response rates to both standard-of-care and new treatments. Despite …

Assessment of composition and biological activity of Arctium lappa leaves extracts obtained with pressurized liquid and supercritical CO2 extraction

ARC de Souza, S Stefanov, MCM Bombardelli… - The Journal of …, 2019 - Elsevier
Pressurized liquid extraction (PLE) of Arctium lappa leaves using aqueous ethanol is
examined and presented for the first time in this work. In addition, global extraction yields …

Chemosensitization of therapy resistant tumors: targeting multiple cell signaling pathways by Lupeol, a pentacyclic triterpene

SK Maurya, G Shadab… - Current Pharmaceutical …, 2020 - ingentaconnect.com
Background: The resistance of cancer cells to different therapies is one of the major
stumbling blocks for successful cancer treatment. Various natural and pharmaceuticals …

In-depth analysis of lupeol: delving into the diverse pharmacological profile

A Dalimunthe, M Carensia Gunawan… - Frontiers in …, 2024 - frontiersin.org
Lupeol, a naturally occurring lupane-type pentacyclic triterpenoid, is widely distributed in
various edible vegetables, fruits, and medicinal plants. Notably, it is found in high …

Syringic acid induces apoptosis in human oral squamous carcinoma cells through mitochondrial pathway

B Abijeth, D Ezhilarasan - Journal of Oral and Maxillofacial …, 2020 - journals.lww.com
Background: Syringic acid (SA) has long been used as traditional medicine and is known to
have antioxidant, hepatoprotective, neuroprotective and anticancer effects. Studies …