Targeting angiogenesis and lymphangiogenesis in kidney disease
K Tanabe, J Wada, Y Sato - Nature Reviews Nephrology, 2020 - nature.com
The kidney is permeated by a highly complex vascular system with glomerular and
peritubular capillary networks that are essential for maintaining the normal functions of …
peritubular capillary networks that are essential for maintaining the normal functions of …
Role of VEGF-A and LRG1 in abnormal angiogenesis associated with diabetic nephropathy
A Zhang, H Fang, J Chen, L He, Y Chen - Frontiers in physiology, 2020 - frontiersin.org
Diabetic nephropathy (DN) is an important public health concern of increasing proportions
and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the …
and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the …
HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury
M Zhao, S Wang, A Zuo, J Zhang, W Wen… - Cellular & Molecular …, 2021 - Springer
Background Endothelial cell (EC) injury accelerates the progression of diabetic
macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible …
macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible …
Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies
Primary congenital glaucoma (PCG) is a severe disease characterized by developmental
defects in the trabecular meshwork (TM) and Schlemm's canal (SC), comprising the …
defects in the trabecular meshwork (TM) and Schlemm's canal (SC), comprising the …
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration
K Shirakura, P Baluk, AF Nottebaum, U Ipe… - EMBO Molecular …, 2023 - embopress.org
Vascular endothelial protein tyrosine phosphatase (VE‐PTP) influences endothelial barrier
function by regulating the activation of tyrosine kinase receptor Tie2. We determined …
function by regulating the activation of tyrosine kinase receptor Tie2. We determined …
[HTML][HTML] Angiopoietin-2 inhibition attenuates kidney fibrosis by hindering chemokine CC motif ligand 2 expression and apoptosis of endothelial cells
FC Chang, CH Liu, AJ Luo, TTM Huang, MH Tsai… - Kidney International, 2022 - Elsevier
Plasma levels of angiopoietin-2 are increased in patients with chronic kidney disease
(CKD). Moreover, mouse models of progressive kidney disease also demonstrate increased …
(CKD). Moreover, mouse models of progressive kidney disease also demonstrate increased …
Peritubular capillary rarefaction: an underappreciated regulator of CKD progression
Y Kida - International Journal of Molecular Sciences, 2020 - mdpi.com
Peritubular capillary (PTC) rarefaction is commonly detected in chronic kidney disease
(CKD) such as hypertensive nephrosclerosis and diabetic nephropathy. Moreover, PTC …
(CKD) such as hypertensive nephrosclerosis and diabetic nephropathy. Moreover, PTC …
VE-PTP inhibition elicits eNOS phosphorylation to blunt endothelial dysfunction and hypertension in diabetes
M Siragusa, AF Oliveira Justo… - Cardiovascular …, 2021 - academic.oup.com
Aims Receptor-type vascular endothelial protein tyrosine phosphatase (VE-PTP)
dephosphorylates Tie-2 as well as CD31, VE-cadherin, and vascular endothelial growth …
dephosphorylates Tie-2 as well as CD31, VE-cadherin, and vascular endothelial growth …
Differential roles of FOXC2 in the trabecular meshwork and Schlemm's canal in glaucomatous pathology
N Ujiie, PR Norden, R Fang, L Beckmann… - Life science …, 2023 - life-science-alliance.org
Impaired development and maintenance of Schlemm's canal (SC) are associated with
perturbed aqueous humor outflow and intraocular pressure. The angiopoietin (ANGPT)/TIE2 …
perturbed aqueous humor outflow and intraocular pressure. The angiopoietin (ANGPT)/TIE2 …
A small molecule inhibitor of VE-PTP activates Tie2 in Schlemm's canal increasing outflow facility and reducing intraocular pressure
G Li, AF Nottebaum, M Brigell… - … & visual science, 2020 - iovs.arvojournals.org
Purpose: Tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2)
activation in Schlemm's canal (SC) endothelium is required for the maintenance of IOP …
activation in Schlemm's canal (SC) endothelium is required for the maintenance of IOP …