The tumor microenvironment (TME) is the tumor surrounding environment, which is critical
for tumor development and progression. TME is also involved in clinical intervention and …

In contemporary oncology, radiation therapy and immunotherapy stand as critical
treatments, each with distinct mechanisms and outcomes. Radiation therapy, a key player in …

Glycosylation, a key mode of protein modification in living organisms, is critical in regulating
various biological functions by influencing protein folding, transportation, and localization …

The effect of the serine/glycine-free diet (− SG diet) on colorectal cancer (CRC) remains
unclear; meanwhile, programmed death-1 (PD-1) inhibitors are less effective for most CRC …

Early screening of biomarkers benefits therapy and prognosis of cancers. MiRNAs
encapsulated in tumor-derived exosomes are emerging biomarkers for early diagnosis of …

Herein, we designed Comp. 1 to simultaneously respond to two enzymes: alkaline
phosphatase and matrix metalloproteinase 2, which is commonly found in highly malignant …

During tumorigenesis and progression, the immune checkpoint programmed death-1 (PD-1)
and its ligand programmed death ligand-1 (PD-L1) play critical roles in suppressing T cell …

Although immune checkpoint-based cancer immunotherapy has shown significant efficacy
in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is …

Abstract Programmed death-ligand 1 (PD-L1) has become a crucial focus in cancer
immunotherapy considering it is found in many different cells. Cancer cells enhance the …

Immune checkpoint inhibition targeting the PD-1/PD-L1 pathway has become a powerful
clinical strategy for treating cancer, but its efficacy is complicated by various resistance …