Synthesis of coumarin-thioether conjugates as potential anti-tubercular agents: Their molecular docking and X-ray crystal studies
In this work, we report a series of 4-(2, 6-dimethylphenyl) thio) methyl)-2H-chromen-2-one
conjugates as promising leads to treat tuberculosis. Spectroscopic and other analytical …
conjugates as promising leads to treat tuberculosis. Spectroscopic and other analytical …
Catalytic role in Biginelli reaction: Synthesis and biological property studies of 2‐oxo/thioxo‐1, 2, 3, 4‐tetrahydropyrimidines
The Biginelli reaction has received significant consideration in recent years due to its easily
accessible aldehyde, urea/thiourea, and active methylene compounds. When it comes to …
accessible aldehyde, urea/thiourea, and active methylene compounds. When it comes to …
Imidazopyridine chalcones as potent anticancer agents: Synthesis, single‐crystal X‐ray, docking, DFT and SAR studies
DK Soumyashree, DS Reddy… - Archiv der …, 2023 - Wiley Online Library
New imidazopyridine–chalcone analogs were synthesized through the Claisen–Schmidt
condensation reaction. The newly synthesized imidazopyridine‐chalcones (S1–S12) were …
condensation reaction. The newly synthesized imidazopyridine‐chalcones (S1–S12) were …
Coumarin Hydrazone Oxime Scaffolds as Potent Anti‐tubercular Agents: Synthesis, X‐ray crystal and Molecular Docking Studies
A series of new Coumarin hydrazone oxime scaffolds were synthesised as potential anti‐TB
agents. The structures of the scaffolds were confirmed by spectroscopic and analytical …
agents. The structures of the scaffolds were confirmed by spectroscopic and analytical …
Microwave produced 8-methyl-1, 2, 4, 8-tetraazaspiro [4.5] dec-2-en-3-amine derivatives: Their in vitro and in silico analysis
Compound 1 is formed by a microwave-assisted multicomponent reaction of 1-
methylpiperidin-4-one, 2-amino-4-methoxy-6-methyl-1, 3, 5-triazine, and thiosemicarbazide …
methylpiperidin-4-one, 2-amino-4-methoxy-6-methyl-1, 3, 5-triazine, and thiosemicarbazide …
Design, synthesis, molecular docking, and biological evaluation of coumarin‐thymidine analogs as potent anti‐TB agents
DS Reddy, A Sinha, MM Kurjogi… - Archiv der …, 2023 - Wiley Online Library
With the intent to discover new antituberculosis (TB) compounds, coumarin‐thymidine
analogs were synthesized using second‐order nucleophilic substitution reactions of …
analogs were synthesized using second‐order nucleophilic substitution reactions of …
Design, synthesis, and anti-mycobacterial evaluation of 1, 8-naphthyridine-3-carbonitrile analogues
Twenty-eight compounds, viz., 1, 8-naphthyridine-3-carbonitrile (ANC and ANA) derivatives,
were designed and synthesized through a molecular hybridization approach. The structures …
were designed and synthesized through a molecular hybridization approach. The structures …
Design and Synthesis of Potent Anticancer Agents Using Coumarin‐Quinazolinone Based Scaffolds: Exploration of ADME Properties and Molecular Docking Studies
Cancer remains a complex global threat causing widespread deaths. Developing effective
anticancer agents despite advancements still remained challenging. In this work it is …
anticancer agents despite advancements still remained challenging. In this work it is …
Microwave Facilitated Discovery of Substituted 1, 2, 4-triazaspiro [4.5] dec-2-en-3-amines: Biological and Computational Investigations
PP Patel, NB Patel, MS Tople, VM Patel… - Current Microwave …, 2023 - ingentaconnect.com
Background: Tuberculosis is an effectual infectious disease caused by the spread of
tubercular bacteria within the lungs via droplets of coughs and sneezes. In 2021, 1.6 million …
tubercular bacteria within the lungs via droplets of coughs and sneezes. In 2021, 1.6 million …